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Updated: Jun 29, 2025
09:29
Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
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Revolutionizing Antiviral Therapeutics: Unveiling Innovative Approaches for Enhanced Drug Efficacy
Sandra Megantara1,2, Agus Rusdin3, Arif Budiman3
1Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, 45363, Indonesia.
International Journal of Nanomedicine
|March 25, 2024
Summary
Modifying antiviral drugs addresses poor solubility and selectivity, enhancing their effectiveness against viral infections. These drug delivery systems show promise for improved clinical therapy.
Area of Science:
- Pharmaceutical Science
- Infectious Diseases
- Drug Delivery
Background:
- Viral infections are a leading cause of global mortality, with antiviral medications being the primary treatment.
- Current antiviral drugs face limitations due to poor physicochemical properties like low solubility and target selectivity.
- Existing research on enhancing antiviral drug properties is fragmented, necessitating a comprehensive review.
Purpose of the Study:
- To systematically review and synthesize modifications aimed at overcoming physicochemical limitations of antiviral drugs.
- To compare the efficacy of various strategies in improving antiviral activity and drug characteristics.
- To provide insights into promising approaches for enhancing antiviral therapies.
Main Methods:
- Systematic literature search across Scopus, PubMed, and Google Scholar databases.
- Analysis of studies reporting modifications to antiviral and antiretroviral drugs.
- Categorization and discussion of modification techniques including liposomes, cocrystals, solid dispersions, salt forms, and nanoparticles.
Main Results:
- Multiple modification strategies effectively addressed physicochemical challenges such as poor aqueous solubility.
- Investigated approaches significantly enhanced the antiviral activity of drug candidates.
- Liposomes, cocrystals, solid dispersions, salt modifications, and nanoparticle systems demonstrated notable improvements.
Conclusions:
- Drug modification techniques offer a viable solution to enhance antiviral drug properties.
- These modifications hold significant promise for improving the functionality and clinical efficacy of antiviral medications.
- Further development and application of these strategies can advance the treatment of viral infections.
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