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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

233
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
233
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

179
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
179
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

145
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
145
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

138
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
138

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Related Experiment Video

Updated: Jun 29, 2025

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
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American Gastroenterological Association-Proposed Fecal Calprotectin Cutoff of 50 ug/g is Associated With Endoscopic

Terry Li1, Ravi Shah2, Benjamin Click3

  • 1Department of Internal Medicine, NYU Grossman School of Medicine, New York, NY, USA.

Crohn'S & Colitis 360
|March 25, 2024
PubMed
Summary
This summary is machine-generated.

A fecal calprotectin (FC) level below 50 ug/g effectively rules out endoscopic recurrence in postoperative Crohn's disease (CD) patients after ileocolic resection (ICR). This finding supports avoiding routine endoscopy in low-risk patients.

Keywords:
Crohn’s diseasefecal calprotectinileocolic resectionpostoperative monitoring

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Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease
  • Clinical Medicine

Background:

  • Fecal calprotectin (FC) is a validated biomarker for active bowel inflammation in Crohn's disease (CD).
  • Current guidelines suggest an FC cutoff of <50 ug/g to potentially avoid routine endoscopy in CD patients with low pretest probability of recurrence.
  • The performance of this FC threshold in a real-world setting after ileocolic resection (ICR) requires evaluation.

Purpose of the Study:

  • To assess the utility of an FC cutoff of <50 ug/g in predicting endoscopic recurrence after ICR in Crohn's disease patients.
  • To determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of this FC threshold.

Main Methods:

  • Retrospective analysis of Crohn's disease patients who underwent ICR between 2009-2020.
  • Inclusion criteria: postoperative FC measurement >60 days and <1 year from surgery, with subsequent colonoscopy.
  • Pretest probability was defined by established risk factors and/or biologic prophylaxis; patients without colonoscopy were excluded.

Main Results:

  • Thirty-seven patients were analyzed; 15 (41%) had FC <50 ug/g and 22 (59%) had FC ≥50 ug/g.
  • No endoscopic recurrence (Rutgeerts score ≥i2b) was observed in the FC <50 ug/g group (0%), compared to 36% in the FC ≥50 ug/g group (P=.005).
  • For an FC cutoff of 50 ug/g, sensitivity was 90%, NPV was 93%, specificity was 48%, and PPV was 38%.

Conclusions:

  • An FC level <50 ug/g is a reliable indicator to exclude endoscopic recurrence in postoperative Crohn's disease patients following ICR.
  • This threshold can aid in identifying low-risk patients who may not require routine endoscopic surveillance.
  • The study validates the <50 ug/g FC cutoff in a real-world clinical scenario for postoperative CD management.