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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

144
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
81
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  3. Neutrophil Percentage As A Potential Biomarker Of Acute Kidney Injury Risk And Short-term Prognosis In Patients With Acute Myocardial Infarction In The Elderly.
  1. Home
  3. Neutrophil Percentage As A Potential Biomarker Of Acute Kidney Injury Risk And Short-term Prognosis In Patients With Acute Myocardial Infarction In The Elderly.

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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Neutrophil Percentage as a Potential Biomarker of Acute Kidney Injury Risk and Short-Term Prognosis in Patients with

Qianwen Chen1, Qingqing Gu1, Anwen Yin2

  • 1Department of Cardiology, the Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, Jiangsu, 213000, People's Republic of China.

Clinical Interventions in Aging
|March 25, 2024

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
acute kidney injuryacute myocardial infarctionneutrophil percentage

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Preoperative neutrophil percentage (NEUT%) is linked to a higher risk of acute kidney injury (AKI) and short-term mortality in acute myocardial infarction (AMI) patients. Higher NEUT% may indicate worse prognosis and disease development.

Area of Science:

  • Cardiology
  • Nephrology
  • Hematology

Background:

  • Acute myocardial infarction (AMI) is a leading cause of cardiovascular mortality.
  • Acute kidney injury (AKI) is a common and serious complication following AMI.
  • Predictive biomarkers for AKI in AMI patients are crucial for risk stratification and management.

Purpose of the Study:

  • To investigate the association between preoperative neutrophil percentage (NEUT%) and the risk of developing AKI in patients undergoing percutaneous coronary intervention for AMI.
  • To evaluate the prognostic value of NEUT% for short-term all-cause mortality in this patient cohort.

Main Methods:

  • A retrospective, observational study included 3001 patients with AMI treated with percutaneous coronary intervention.
  • Patients were categorized into AKI and non-AKI groups.
  • Univariate and multivariable logistic regression analyses were performed to assess the association of NEUT% with AKI risk. Kaplan-Meier curves evaluated prognostic ability for mortality.

    • Main Results:

    • AKI developed in 10.9% of patients (327/3001).
    • Preoperative NEUT% was significantly higher in the AKI group compared to the non-AKI group (76.65±11.43% vs. 73.22±11.83%, P<0.001).
    • Elevated NEUT% was an independent risk factor for AKI (OR=1.021, P<0.001) and was associated with increased short-term all-cause mortality (Log rank P<0.001).

    Conclusions:

    • Preoperative neutrophil percentage is positively associated with the risk of AKI in patients with AMI.
    • Higher NEUT% is also linked to increased short-term all-cause mortality after AMI.
    • NEUT% may serve as a valuable biomarker for predicting AKI and prognosis in AMI patients.