Jove
Visualize
Contact Us

Related Concept Videos

Cancer Survival Analysis01:21

Cancer Survival Analysis

345
Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
345
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

404
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
404
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.6K
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Clinical Characteristics And Prognostic Factors Of Male Breast Cancer In China.
  1. Home
  3. Clinical Characteristics And Prognostic Factors Of Male Breast Cancer In China.

Related Experiment Video

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

261

Clinical characteristics and prognostic factors of male breast cancer in China.

Han Lei1, Baojie Hua2, Yingying Mao2

  • 1The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.

Frontiers in Oncology
|March 25, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

This study identifies age, tumor stage, and differentiation grade as key prognostic factors for male breast cancer (MBC). Inflammatory markers like LMR, PLR, and NLR show potential for predicting MBC outcomes.

Keywords:
disease-free survivalmale breast cancernomogramoverall survivalprognosis

More Related Videos

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.0K
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.1K

Related Experiment Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

261
Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

9.0K
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

13.1K

Area of Science:

  • Oncology
  • Clinical Research
  • Cancer Prognostics

Background:

  • Male breast cancer (MBC) is rare, necessitating research into its specific clinical characteristics and prognostic indicators.
  • Understanding factors influencing MBC prognosis is crucial for tailoring treatment strategies and improving patient outcomes.

Purpose of the Study:

  • To investigate the clinical features of male breast cancer (MBC) patients.
  • To identify factors that predict prognosis in male breast cancer.

Main Methods:

  • Retrospective analysis of 115 male breast cancer cases treated between 2009 and 2022.
  • Utilized Cox proportional hazard models to determine prognostic factors for overall survival (OS) and disease-free survival (DFS).
  • Developed and validated nomograms for predicting DFS using C-index and calibration curves.

Main Results:

  • The median age of diagnosis for MBC was 59 years. Most cases were estrogen receptor (ER) and progesterone receptor (PR) positive.
  • Lymphocyte-to-monocyte ratio (LMR), platelet-to-lymphocyte ratio (PLR), and neutrophil-to-lymphocyte ratio (NLR) were associated with survival outcomes.
  • Age, histological differentiation grade, and TNM stage were significant predictors of DFS, with nomograms showing good predictive performance (C-index 0.782).

Conclusions:

  • Advanced age, larger tumor size, higher TNM stage, and poor histological differentiation are linked to worse MBC prognosis.
  • Inflammatory markers such as LMR, PLR, and NLR may serve as potential predictive biomarkers for male breast cancer prognosis.