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Updated: Jun 29, 2025
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
N6-methylation in the development, diagnosis, and treatment of gastric cancer
Jiaxin Wang1, Guiping Zhao1, Yan Zhao1
1Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Abstract:
Gastric cancer (GC) ranks third among cancers in terms of mortality rate worldwide. A clear understanding of the mechanisms underlying the genesis and progression of GC will contribute to clinical decision making. N6-methyladenosine (m6A) is the most abundant among diverse mRNA modification types and regulates multiple facets of RNA metabolism. In recent years, emerging studies have shown that m6A modifications are involved in gastric carcinoma tumorigenesis and progression and can potentially be valuable new prospects for diagnosis and prognosis. This article reviews the recent progress regarding m6A in GC.
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