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Methods to Explore the Influence of Top-down Visual Processes on Motor Behavior
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The TOPOS study.

Tim Sebastian1, Stefano Barco1,2, Davide Voci1

  • 1Department of Angiology, University Hospital Zurich, Switzerland.

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|March 25, 2024
PubMed
Summary
This summary is machine-generated.

Oblique venous stents safely treat post-thrombotic syndrome (PTS) with iliac vein compression, maintaining high patency and significantly reducing symptoms over 24 months.

Keywords:
May-Thurner syndrome; stent patencyangioplastypost-thrombotic syndromesinus-Obliquus stentvenous thromboembolism

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Area of Science:

  • Vascular Surgery
  • Interventional Cardiology
  • Venous Thromboembolism

Background:

  • Post-thrombotic syndrome (PTS) with iliac vein compression significantly impacts patient quality of life.
  • Endovascular treatment is a key therapeutic option for managing PTS.
  • Long-term safety and efficacy data for specific venous stents in PTS are crucial.

Purpose of the Study:

  • To evaluate the long-term safety and efficacy of oblique venous stents for PTS.
  • To assess primary stent patency and clinical outcomes at 24 months.
  • To analyze the impact on PTS severity scores and quality of life.

Main Methods:

  • Prospective, single-arm, multinational TOPOS study.
  • 60 PTS patients received sinus-Obliquus® stent, with optional distal extensions.
  • Primary endpoint: 24-month primary stent patency; secondary: Villalta score, rVCSS, VAS, CIVIQ-20, complications.

Main Results:

  • 24-month primary patency rate was 80.7%.
  • Significant reductions in Villalta score, rVCSS, pain VAS, and CIVIQ-20 (p<.001).
  • Low rates of acute stent occlusion (9) and symptomatic stenosis (4); no major bleeding or contralateral thrombosis.

Conclusions:

  • Endovascular treatment with oblique stents and extensions is safe for PTS.
  • High patency rates and substantial, persistent reduction in PTS severity observed at 24 months.
  • Supports the use of oblique venous stents for managing iliac vein compression in PTS.