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Updated: Jun 29, 2025

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Krüppel-like factor 2 (KLF2), a potential target for neuroregeneration

Surajit Hansda1, Prateeksha Prateeksha, Hiranmoy Das

  • 1Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, USA.

Neural Regeneration Research
|March 25, 2024
PubMed
Summary

No abstract available in PubMed .

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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