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Updated: Jun 29, 2025

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages
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Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Published on: November 3, 2014

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Lipopolysaccharide Regulates the Macrophage RNA-Binding Proteome

Deepali Rathore1, Matthew J Marino1, Jiraphorn Issara-Amphorn1

  • 1Functional Cellular Networks Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, United States.

Journal of Proteome Research
|March 25, 2024
PubMed
Summary

This study reveals how RNA-protein interactions regulate innate immunity. Researchers identified key RNA binding proteins (RBPs) that change their RNA binding activity after lipopolysaccharide (LPS) stimulation in macrophages.

Keywords:
RNA-binding proteinsTLR signalingcell signalinginnate immunitymacrophagesprotein−RNA interactionsproteomics

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