Effectiveness of Computerized Cognitive Training on Working Memory in Pediatric Cancer Survivors: A Systematic Review...

Area of Science:

• Neuroscience
• Pediatric Oncology
• Cognitive Psychology

Background:

• Computerized cognitive training (CCT) offers a potentially low-cost intervention for pediatric cancer survivors.
• A comprehensive review on CCT's effectiveness for improving working memory (WM) in this population is currently lacking.

Purpose of the Study:

• To systematically review and synthesize evidence on the efficacy of CCT for enhancing WM in pediatric cancer survivors.
• To evaluate the impact of CCT on secondary cognitive functions and intervention adherence.

Main Methods:

• A systematic search of five databases was conducted.
• Study quality was assessed using the Effective Public Health Practice Project.
• WM performance was the primary outcome, with processing speed and attention as secondary outcomes.

Main Results:

• Six studies met the inclusion criteria, with five demonstrating significant WM improvements post-intervention.
• A meta-analysis of Cogmed interventions showed a significant positive effect on symbolic WM (pooled effect size = 0.71, P = .04).
• Effects on processing speed and attention were inconsistent across studies; adherence was generally high (≥80%), with no reported adverse events.

Conclusions:

• Computerized cognitive training, specifically Cogmed, demonstrates a significant positive impact on working memory in pediatric cancer survivors.
• The effects of CCT on processing speed and attention require further investigation through more rigorous trials.
• Future research should explore combining CCT with other interventions to maximize cognitive benefits.