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Updated: Jun 29, 2025
Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Soluble Biomarkers of Cerebrovascular Pathologies
Kate E Foley1,2, Donna M Wilcock1,2
1Stark Neurosciences Research Institute (K.E.F., D.M.W.), Indiana University, Indianapolis.
Blood-based biomarkers for vascular contributions to cognitive impairment and dementia (VCID) are emerging. This review explores promising candidates and ongoing initiatives to detect VCID, which often co-occurs with Alzheimer disease.
Area of Science:
- Neurology
- Neuroscience
- Biomarker Discovery
Background:
- Vascular contributions to cognitive impairment and dementia (VCID) describes cognitive decline from cerebrovascular issues.
- VCID frequently co-occurs with Alzheimer disease, complicating diagnosis and treatment.
- Current blood-based biomarkers for Alzheimer disease are advanced, but VCID biomarkers are nascent.
Purpose of the Study:
- To review current pathways for identifying blood-based biomarkers of cerebrovascular dysfunction.
- To highlight promising candidate biomarkers for VCID.
- To describe ongoing initiatives in VCID blood-based biomarker discovery.
Main Methods:
- Literature review of imaging and pathological studies.
- Analysis of research pathways for cerebrovascular dysfunction markers.
- Summary of ongoing biomarker discovery initiatives.
Main Results:
- VCID is a heterogeneous condition with diverse pathological and temporal characteristics.
- Several promising candidate blood-based biomarkers are emerging for VCID.
- Significant efforts are underway to develop sensitive and specific VCID biomarkers.
Conclusions:
- Developing blood-based biomarkers for VCID is crucial due to its prevalence and comorbidity with Alzheimer disease.
- Despite challenges, progress is being made in identifying reliable VCID markers.
- Future research will focus on validating and implementing these biomarkers for clinical use.
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