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Updated: Jun 29, 2025
Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
Published on: February 6, 2019
Low Dose Radiation and Solid Tumors Mortality Risk
Xuguang Grant Tao1, Frank C Curriero, Mahadevappa Mahesh
1From the Division of Occupational and Environmental Medicine, Department of Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland (T.G.X.); Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland (F.C.C.), and the Russell H. Morgan Department of Radiology and Radiological Science and Division of Cardiology Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland (M.M.).
Background:
US nuclear capable shipyard workers have increased potential for occupational radiation exposure.
Objective:
The aim of the study is to examine solid tumor mortality risks at low doses.
Method:
437,937 workers working from 1957 to 2004 at eight US shipyards were studied.
Results:
Radiation workers with a median life-time dose at 0.82 mSv had a significantly lower solid tumor mortality risk (relative risk [RR]: 0.96, 95% confidence interval [CI]: 0.94-0.98) than nonradiation workers. Among 153,930 radiation workers, the RRs of solid tumors increased with increasing dose categories without statistical significance. The dose category >0-<25 mSv had significantly lower RR (0.95, 95% CI: 0.91-0.99) versus 0 dose and the excess relative risk was 0.05/100 mSv (95% CI: 0.01-0.08).
Conclusions:
Solid tumor risk might increase with radiation dose, but not linearly at low doses. Actual mortality risk may be dependent on dose received.
