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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Updated: Jun 29, 2025

HPLC-based Assay to Monitor Extracellular Nucleotide/Nucleoside Metabolism in Human Chronic Lymphocytic Leukemia Cells
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Long Non-Coding RNA RP11-252C15.1 Is a Potential Biomarker of Prognosis and Hallmark for Leukemogenesis in Children

Lili Pan1, Yongzhi Zheng1, Hao Zheng1

  • 1Pediatric Hematology Department, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fuzhou, China.

Acta Haematologica
|March 25, 2024
PubMed
Summary
This summary is machine-generated.

Researchers identified two long non-coding RNAs (lncRNAs) in childhood acute lymphoblastic leukemia (ALL). LncRNA RP11-252C15.1 shows potential as an oncogene and prognostic biomarker in B-cell precursor ALL.

Keywords:
Acute lymphoblastic leukemiaLeukemiaLong non-coding RNALymphoblastic leukemiaPrognosis

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Accurate risk stratification in childhood acute lymphoblastic leukemia (ALL) requires improved understanding of prognostic biomarkers.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cancer development and progression.

Purpose of the Study:

  • To identify novel long non-coding RNA (lncRNA) biomarkers in childhood ALL.
  • To evaluate the prognostic value of identified lncRNAs in pediatric ALL patients.

Main Methods:

  • RNA sequencing to identify differentially expressed lncRNAs in ALL patients compared to controls.
  • Reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) for validation.
  • Correlation analysis to assess relationships between lncRNAs, clinical features, and outcomes.
  • In vitro experiments to investigate the functional role of candidate lncRNAs.

Main Results:

  • 1,019 differentially expressed lncRNAs were identified between ALL and control groups.
  • LncRNA RP11-252C15.1 and lncRNA RP11-701P16.2 were significantly upregulated in ALL patients.
  • LncRNA RP11-252C15.1 demonstrated prognostic value and was associated with clinical features in B-cell precursor ALL (BCP-ALL).
  • In vitro studies confirmed lncRNA RP11-252C15.1 overexpression in BCP-ALL cell lines, promoting proliferation and inhibiting apoptosis.

Conclusions:

  • LncRNA RP11-252C15.1 functions as a potential oncogene in BCP-ALL pathogenesis.
  • LncRNA RP11-252C15.1 serves as a valuable prognostic biomarker for children with BCP-ALL.