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Updated: Jun 29, 2025
11:06
Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
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Dietary Supplement-Induced Hepatotoxicity: A Clinical Perspective
Jordan Carty1, Victor J Navarro1
1Department of Medicine, Jefferson Einstein Medical Center, Philadelphia, PA, USA.
Journal of Dietary Supplements
|March 26, 2024
Summary
Dietary supplements (DS) increasingly cause liver injury. Understanding DS hepatotoxicity, diagnosis, and causality is vital for clinicians and consumers to prevent harm.
Area of Science:
- Hepatology
- Clinical Toxicology
- Nutritional Science
Background:
- Dietary supplements (DS) consumption is linked to a rising incidence of liver injury.
- Clinicians and consumers require comprehensive information on DS adverse effects for prompt action.
Purpose of the Study:
- To provide a clinical perspective on dietary supplement-related hepatotoxicity.
- To highlight diagnostic approaches and causality assessment for DS-induced liver injury.
- To discuss current and emerging DS implicated in liver damage, such as Garcinia Cambogia, turmeric, and ashwagandha.
Main Methods:
- Systematic review of clinical cases and literature on DS-related hepatotoxicity.
- Analysis of causality assessment tools for DS-induced liver injury.
- Examination of regulatory standards and knowledge gaps.
Main Results:
- DS are a significant cause of drug-induced liver injury.
- Specific supplements like Garcinia Cambogia, turmeric, and ashwagandha have been associated with hepatotoxicity.
- Causality assessment tools are essential but have limitations.
Conclusions:
- A systematic diagnostic approach and understanding of DS are crucial for preventing liver injury.
- Enhanced clinician and consumer education on DS risks is necessary.
- Collaborative efforts are required to mitigate DS-related hepatotoxicity.
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