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Penile Calciphylaxis: A Successfully Treated Case

Narine Misakyan1, Amer Abu-Shanab2, Shazia Shah2

  • 1Internal Medicine, Capital Health Medical Center, Trenton, USA.

Cureus
|March 26, 2024
PubMed

Insights

Penile calciphylaxis, a rare condition in dialysis patients, involves painful skin necrosis. This case study highlights successful treatment with combined interventions, leading to complete healing.

Area of Science:

  • Nephrology
  • Dermatology
  • Vascular Surgery

Background:

  • Penile calciphylaxis is a rare, life-threatening manifestation of calcific uremic arteriolopathy, primarily affecting patients with end-stage renal disease (ESRD) on hemodialysis.
  • The exact cause is unknown, but it involves calcium deposition in small blood vessels, leading to tissue ischemia, necrosis, and painful ulcerations.
  • ESRD and diabetes are significant risk factors, increasing the likelihood of developing this condition.

Observation:

  • A 53-year-old male with ESRD and diabetes on hemodialysis presented with severe penile pain and black discoloration.
  • The patient's symptoms developed over five days, indicating an acute and severe presentation.
  • Clinical examination and diagnosis confirmed penile calciphylaxis.

Findings:

  • The patient received a combination of conservative management and surgical interventions.
  • The treatment approach resulted in a highly positive outcome for the patient.
  • Complete healing of the affected penile tissue was achieved without complications.

Implications:

  • This case demonstrates the efficacy of a multimodal treatment strategy for penile calciphylaxis.
  • Successful management can lead to complete recovery, mitigating risks of sepsis and mortality associated with the condition.
  • Further research into the etiopathogenesis and optimal treatment protocols for penile calciphylaxis is warranted.

Keywords:
end stage renal disease (esrd)ischemiapenile calciphylaxissodium thiosulfatetypes 2 diabetes

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