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Epigenetic Regulation01:37

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Updated: Jun 29, 2025

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Upregulation and epigenetic modification of the creatine transporter SLC6A8 in non-small cell lung cancer.

Christiane Kuempers1,2, Karoline Schnepf3, Sebastian Marwitz2,4

  • 1Institute of Pathology, University Hospital Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. christiane.kuempers@uksh.de.

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|March 26, 2024
PubMed
Summary
This summary is machine-generated.

Creatine transporter SLC6A8 is upregulated in non-small cell lung cancer (NSCLC), with higher expression linked to poorer prognosis, especially in male smokers with lung adenocarcinoma. This suggests SLC6A8 is a potential therapeutic target for NSCLC.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Epigenetics

Background:

  • Non-small cell lung cancer (NSCLC) remains a leading cause of cancer mortality with limited therapeutic options.
  • Cellular respiration is altered in tumors, presenting a potential therapeutic target.
  • Creatine transport, mediated by the creatine transporter SLC6A8, is a key aspect of cellular respiration.

Purpose of the Study:

  • To investigate the expression of SLC6A8 at RNA and protein levels in NSCLC.
  • To analyze epigenetic modifications of the SLC6A8 gene in NSCLC.
  • To evaluate the prognostic significance of SLC6A8 expression in NSCLC patients.

Main Methods:

  • Analysis of epigenetic modifications and transcriptome in 32 NSCLC patients.
  • Immunohistochemistry to assess SLC6A8 protein expression in an independent cohort.
  • Kaplan-Meier survival analysis in a cohort of 1925 NSCLC patients.

Main Results:

  • SLC6A8 gene loci are epigenetically modified in NSCLC compared to controls.
  • SLC6A8 is upregulated at both RNA and protein levels in NSCLC.
  • High SLC6A8 mRNA expression correlates with poor prognosis in lung adenocarcinoma, particularly in male smokers.

Conclusions:

  • The creatine transporter SLC6A8 plays a significant role in NSCLC.
  • SLC6A8 may serve as a prognostic biomarker and a potential therapeutic target for NSCLC.