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Three-dimensional Biomimetic Technology: Novel Biorubber Creates Defined Micro- and Macro-scale Architectures in Collagen Hydrogels

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Biofabrication Strategies for Oral Soft Tissue Regeneration.

Maedeh Rahimnejad¹, Hardik Makkar², Renan Dal-Fabbro¹

¹Department of Cariology, Restorative Sciences, and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, 48109, USA.

Advanced Healthcare Materials

|March 26, 2024

Summary

Gingival tissue engineering offers innovative solutions for gum recession, moving beyond traditional treatments. Advanced biofabrication techniques precisely control cells and materials for realistic gingival grafts, promising better dental outcomes.

Keywords:

biofabrication bioprinting gingival recession regeneration skin tissue engineering

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Area of Science:

Regenerative Dentistry
Biomaterials Science
Tissue Engineering

Background:

Gingival recession, a common gum condition, exposes tooth roots due to gingival margin displacement.
Conventional treatments for gingival recession have limitations, driving the need for novel alternatives.
Gingival tissue engineering is explored as a promising regenerative approach.

Purpose of the Study:

To review critical considerations in gingival tissue engineering, focusing on cells, biomaterials, and signaling factors.
To explore advancements in biofabrication technologies for creating functional gingival constructs.
To highlight potential applications of skin tissue regeneration strategies in gingival tissue engineering.

Main Methods:

Review of current literature on gingival tissue engineering strategies.
Analysis of biofabrication technologies including 3D bioprinting, electrospinning, and microfluidic systems.
Examination of cell sources, scaffold design, mechanical properties, and growth factor delivery.

Main Results:

Biofabrication technologies offer precise control over cell arrangement, biomaterials, and signaling cues for gingival constructs.
Engineered gingival constructs can emulate the anatomical, physiological, and functional characteristics of native tissues.
Parallels between skin and gingival tissues suggest transferable biofabrication approaches.

Conclusions:

Strategic choices in cell sources, scaffolds, and signaling factors are crucial for successful gingival tissue engineering.
Innovative biofabrication technologies are paving the way for realistic tissue-engineered gingival grafts.
The integration of biofabrication and insights from skin regeneration holds potential for transformative advancements in regenerative dentistry.