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Updated: Jun 29, 2025
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Acute kidney injury in children with lymphoma
Insights
Acute kidney injury (AKI) affects 16.5% of children with lymphoma, with tumor lysis syndrome, lung infection, and advanced stage being key risk factors. Early awareness is crucial as AKI increases mortality risk.
Area of Science:
- Pediatric Nephrology
- Pediatric Oncology
- Critical Care Medicine
Background:
- Acute kidney injury (AKI) is a significant concern in pediatric oncology.
- Understanding AKI epidemiology in children with lymphoma is crucial for timely intervention.
- Limited data exists on AKI incidence and risk factors in this specific population.
Purpose of the Study:
- To determine the incidence of AKI in children with lymphoma within 30 days of hospitalization.
- To identify risk factors associated with AKI development in pediatric lymphoma patients.
- To evaluate the impact of AKI on renal function and mortality over a 1-year follow-up.
Main Methods:
- Retrospective analysis of electronic health records for children diagnosed with lymphoma (2020-2021).
- AKI diagnosis based on Kidney Disease Improving Global Outcomes (KDIGO) criteria.
- Statistical analysis of risk factors, mortality, and renal recovery.
Main Results:
- 16.5% of 295 children with lymphoma developed AKI within 30 days.
- Independent risk factors for AKI included tumor lysis syndrome (TLS), lung infection, and advanced lymphoma stage (Stage 4).
- AKI was associated with higher mortality, but survivors showed no long-term renal impairment.
Conclusions:
- Tumor lysis syndrome, lung infection, and advanced lymphoma stage are significant risk factors for AKI in children.
- Increased clinical vigilance for AKI in hospitalized lymphoma patients is recommended.
- Prompt management of AKI may improve outcomes in pediatric lymphoma.
Objective:
To analyze the epidemiology of acute kidney injury (AKI) in children with lymphoma and to assess the incidence, risk profile of AKI, and effects on renal function in children with lymphoma during their first 30 days of hospitalization.
Materials And Methods:
This was a retrospective screen of electronic hospital and laboratory databases to select hospitalized children who were first diagnosed and treated for lymphoma at Beijing Children's Hospital between 2020 and 2021. AKI was defined according to the Kidney Disease Improving Global Outcomes criteria. We analyzed the incidence and risk factors for AKI in children with lymphoma during their first 30 days of hospitalization. We also analyzed mortality rate and the incidence of kidney recovery over a 1-year follow-up period.
Results:
Of the 295 children with lymphoma (which were all non-Hodgkin lymphoma), 42 (16.5%) experienced AKI events during the first their 30 days of hospitalization. The proportion of patients with lymphoma clinical stage 4 was higher in the AKI group than in the non-AKI group (66.7 vs. 43.7%, p < 0.05). Tumor lysis syndrome (TLS), lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma. Severe AKI was associated with TLS, sepsis, and a higher need for intensive care. Over 1-year of follow-up, none of the survivors developed impaired renal function or proteinuria. However, the mortality of children in the AKI group was significantly higher than that in the non-AKI group (p < 0.05).
Conclusion:
TLS, lung infection, and lymphoma clinical stage were identified as independent risk factors for AKI in children with lymphoma during the first 30 days of hospitalization. Clinicians should increase their awareness of AKI in hospitalized patients with lymphoma.
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