Related Experiment Video
Updated: Jun 29, 2025

06:20
Syngeneic Mouse Orthotopic Allografts to Model Pancreatic Cancer
Published on: October 4, 2022
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Unlocking the Pancreatic Cancer Puzzle: Using Intermediate Cells to Target Treatment
Erika Y Faraoni1, Florencia McAllister2,3,4
1Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Abstract:
KRT17-high intermediate cell population with elevated CXCL8 expression informed elevated myeloid infiltration status in tumors and associated with protumorigenic signatures in peripheral granulocytes from patients with pancreatic cancer. Furthermore, CXCL8 plasma levels were found to resemble KRT17+/CXCL8+ abundance in tumors, in which higher levels predicted worse patient outcomes. See related article by Carpenter et al., p. 2497.

