Important Radiologic and Clinical Factors for Predicting Overall Survival in Pancreatic Adenocarcinoma Patients Who...

Area of Science:

• Oncology
• Radiology
• Medical Imaging

Background:

• Pancreatic adenocarcinoma (PAC) presents a significant challenge in predicting patient outcomes.
• FOLFIRINOX is a standard chemotherapy regimen for PAC, but predicting survival remains crucial.

Purpose of the Study:

• To identify predictors of poor overall survival (OS) in PAC patients undergoing FOLFIRINOX treatment.
• To develop a computed tomography (CT)-based nomogram for OS prediction.

Main Methods:

• Retrospective analysis of 189 PAC patients treated with FOLFIRINOX.
• Assessment of CT findings, including tumor size changes (RECIST 1.1) and resectability.
• Utilized Cox proportional hazard models and constructed a CT-based nomogram.

Main Results:

• Baseline CT features like rim enhancement and high delta tumor size were associated with poor prognosis.
• Progressive disease on follow-up CT and absence of surgery significantly predicted worse OS.
• The developed nomogram demonstrated good predictive accuracy for survival.

Conclusions:

• Clinical and CT imaging findings are valuable tools for predicting OS in PAC patients receiving FOLFIRINOX.
• CT-based nomograms can aid in prognostication and treatment planning.