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Updated: Aug 17, 2026
Polymer Microarrays for High Throughput Discovery of Biomaterials
Published on: January 25, 2012
Merging Modular Molecular Design with High Throughput Screening of Cell Adhesion on Antimicrobial Supramolecular
Moniek G J Schmitz1, Jasper G M Aarts1, Laurence Burroughs2
1Department of Biomedical Engineering, Institute for Complex Molecular Systems (ICMS), Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
Abstract:
A polymer microarray based on the supramolecular ureido-pyrimidinone (UPy) moiety is fabricated to screen antimicrobial materials for their ability to support cell adhesion. UPy-functionalized additives, either cell-adhesive, antimicrobial or control peptides, are used, and investigated in different combinations at different concentrations, resulting in a library of 194 spots. These are characterized on composition and morphology to evaluate the microarray fabrication. Normal human dermal fibroblasts are cultured on the microarrays and cell adhesion to the spots is systematically analyzed. Results demonstrate enhanced cell adhesion on spots with combinations including the antimicrobial peptides. This study clearly proves the power of the high throughput approach in combination with supramolecular molecules, to screen additive libraries for desired biological response.
