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A sensitivity-enhanced plasmonic sensing platform modified with Co(OH)2 nanosheets.

Yanpei Xu1, Haoyu Wu1, Meng Sun1

  • 1College of Sciences, Northeastern University, Shenyang, 110819, China.

Biosensors & Bioelectronics
|March 26, 2024
PubMed
Summary

This study introduces a novel Ag-TiO2-Co(OH)2 nanosheet structure for enhanced surface plasmon resonance (SPR) sensors. The new design significantly boosts sensitivity for biomolecule detection, offering a highly sensitive platform for immunoassays.

Keywords:
FEM simulationHexagonal multi-grooved Co(OH)(2)Human serum albuminPlasmonic interfaceRefractive index sensingSpecific bindingnanosheets

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Area of Science:

  • Materials Science
  • Biotechnology
  • Analytical Chemistry

Background:

  • Surface Plasmon Resonance (SPR) sensors are crucial for biomolecule detection but require high sensitivity.
  • Existing SPR sensors face limitations in sensitivity for certain applications.
  • Developing advanced plasmonic interfaces is key to improving SPR sensor performance.

Purpose of the Study:

  • To develop a sensitivity-enhanced functionalized plasmonic interface for SPR sensors.
  • To investigate the structural and compositional effects of Ag-TiO2-Co(OH)2 nanosheets on SPR sensitivity.
  • To enable specific and sensitive detection of biomolecules, such as human serum albumin (HSA).

Main Methods:

  • Fabrication of a novel plasmonic interface using Ag-TiO2-Co(OH)2 nanosheets.
  • Characterization of the nanosheet structure and its properties.
  • Integration of the functionalized interface with an SPR sensing platform.
  • Application of a double-antibody sandwich method for specific biomolecule detection.

Main Results:

  • The Ag-TiO2-Co(OH)2 nanosheet structure significantly enhanced SPR sensor sensitivity by 130.84% compared to unmodified sensors, reaching 5764.27 nm/RIU.
  • The enhancement is attributed to the high refractive index of the coating and the unique properties of Co(OH)2 nanosheets (high surface area, active sites, multi-grooved structure).
  • The antibody-functionalized sensor demonstrated specific detection of human serum albumin (HSA) with a wide linear response range (0.4-150 μM) and a low limit of detection (LOD) of 154.89 nM.

Conclusions:

  • The proposed Ag-TiO2-Co(OH)2 nanosheet-based plasmonic interface provides a highly sensitive platform for SPR biosensing.
  • This novel structure offers a new strategy for developing advanced biochemical sensors and immunoassays.
  • The enhanced sensitivity and specificity pave the way for improved diagnostic tools and research applications.