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  3. Incidence And Clinical Manifestations Of Giant Cell Arteritis In Spain: Results Of The Arteser Register.
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  3. Incidence And Clinical Manifestations Of Giant Cell Arteritis In Spain: Results Of The Arteser Register.

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Incidence and clinical manifestations of giant cell arteritis in Spain: results of the ARTESER register.

Delia Fernández-Lozano1, Iñigo Hernández-Rodríguez2, Javier Narvaez3

  • 1Rheumatology, Hospital Clinico Universitario de Valencia, Valencia, Spain.

RMD Open
|March 26, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

The incidence of giant cell arteritis (GCA) in Spain is 7.42 per 100,000 people over 50, primarily affecting women and those aged 80-84. GCA shows no significant geographical or seasonal variation.

Keywords:
epidemiologygiant cell arteritisincidencevasculitis

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Area of Science:

  • Rheumatology
  • Epidemiology
  • Internal Medicine

Background:

  • Giant cell arteritis (GCA) is a systemic vasculitis affecting large arteries, predominantly the aorta and its branches.
  • Early diagnosis and treatment are crucial to prevent severe complications such as vision loss and stroke.

Purpose of the Study:

  • To estimate the incidence of GCA in Spain.
  • To analyze the clinical manifestations and epidemiological distribution of GCA by age, sex, geography, and season.

Main Methods:

  • A retrospective study of 1675 patients diagnosed with GCA between June 2013 and March 2019 across 26 hospitals in Spain.
  • Inclusion criteria: age ≥50 years, positive diagnostic test (biopsy/imaging), or meeting ACR criteria/physician diagnosis.
  • Incidence rate calculated using Poisson regression, with analysis of demographic and seasonal factors.

Main Results:

  • The annual incidence of GCA was estimated at 7.42 cases per 100,000 individuals aged ≥50 years.
  • Incidence peaked in the 80-84 age group (23.06 per 100,000) and was significantly higher in women (10.06) than men (4.83).
  • No significant differences in incidence were observed based on geographical distribution or season.

Conclusions:

  • This is the first national-level incidence study of GCA in Spain.
  • GCA predominantly affects women in their ninth decade of life.
  • The findings indicate a lack of significant geographical or seasonal variability in GCA incidence in Spain.