Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acute medicine and the urgent care crisis: From pressure point to system solution.

Future healthcare journal·2026

Same author

Analytical and Clinical Validity of a High-Throughput, Fully Automated Immunoassay for Plasma Neurofilament Light Chain.

The journal of applied laboratory medicine·2026

Same author

High-resolution profiling of osteocyte transcriptomes via single-nucleus RNA sequencing.

JBMR plus·2026

Same author

Automating the quality monitoring of a hospital discharge summary improvement project utilising large language models.

NPJ digital medicine·2026

Same author

An automated plasma-based proteotyping immunoassay for APOE ε4 zygosity classification in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Generation and characterization of a novel inducible Sost_P2A_CreERT2 mouse model with high specificity for osteocytes.

JBMR plus·2026

Same journal

A Physiologic Left Ventricle Flow Phantom for 4D Flow MRI Applications and CFD Verification.

Annals of biomedical engineering·2026

Same journal

Pulsatile Hemodynamics of Prehypertension and Hypertension: Associations with Pressure and Sex.

Annals of biomedical engineering·2026

Same journal

A Pressure Difference-Based Strategy for Blood Oxygen Control in Membrane Oxygenators: Reduced Modeling, Computational Simulation, and Exploratory In Vivo Evaluation.

Annals of biomedical engineering·2026

Same journal

Multidirectional Optical Bone Densitometry Using a Simulation-Based Machine Learning Model: Experimental Validation with Bone Phantoms.

Annals of biomedical engineering·2026

Same journal

Numerical Study of Human Torso Mechanical Response and Injury Assessment Under Blast Loading with Bulletproof Protection.

Annals of biomedical engineering·2026

Same journal

Immediate and Mid-Long-Term Effects of Foot Orthoses on Gait Biomechanics and Clinical Characteristics in Medial Knee Osteoarthritis: A Systematic Review and Meta-analysis.

Annals of biomedical engineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 29, 2025

Author Spotlight: EasyFlow - An Economical and Adaptable Perfusion Bioreactor for Large Blood Vessel Culture

Author Spotlight: EasyFlow - An Economical and Adaptable Perfusion Bioreactor for Large Blood Vessel Culture

Published on: July 28, 2023

The 'bIUreactor': An Open-Source 3D Tissue Research Platform.

Elizabeth Butch¹, Matthew Prideaux², Mark Holland¹

¹Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.

Annals of Biomedical Engineering

|March 27, 2024

Summary

This summary is machine-generated.

Researchers can now study 3D structured tissues affordably with the open-source bIUreactor platform. This versatile system enables 3D tissue generation, perfusion, and mechanical loading in any lab for under $8,000.

Keywords:

3D printing 3D tissue Biofabrication Bioprinting Bioreactor Hardware Open-source Tissue culture Tissue engineering

More Related Videos

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

Tissue Engineering of a Human 3D in vitro Tumor Test System

Tissue Engineering of a Human 3D in vitro Tumor Test System

Published on: August 6, 2013

Related Experiment Videos

Last Updated: Jun 29, 2025

Author Spotlight: EasyFlow - An Economical and Adaptable Perfusion Bioreactor for Large Blood Vessel Culture

Author Spotlight: EasyFlow - An Economical and Adaptable Perfusion Bioreactor for Large Blood Vessel Culture

Published on: July 28, 2023

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Designing a Bioreactor to Improve Data Acquisition and Model Throughput of Engineered Cardiac Tissues

Published on: June 2, 2023

Tissue Engineering of a Human 3D in vitro Tumor Test System

Tissue Engineering of a Human 3D in vitro Tumor Test System

Published on: August 6, 2013

Area of Science:

Biomedical Engineering
Tissue Engineering
Open-Source Technology

Background:

Studying 3D structured tissues is crucial for advancing biomedical research.
Existing bioreactor systems can be expensive and inaccessible for many laboratories.

Purpose of the Study:

To develop an affordable, open-source research platform for studying 3D structured tissues.
To enable researchers to generate, culture, and apply mechanical stimuli to 3D tissues in their own labs.

Main Methods:

Leveraging 3D printing, open-source software, and hardware to create a modular bioreactor system.
Integrating components for perfusible 3D tissue generation, oxygenated perfusion, and cyclic compression.
Developing open-source code for controlling the bioreactor system.

Main Results:

The bIUreactor platform successfully enables the generation and culture of perfusible 3D tissues.
The system incorporates a bioreactor chamber, cyclic compression module, and peristaltic pump for oxygenated perfusion.
The complete system, including a 3D printer and electronics, costs approximately $8,000.

Conclusions:

The open-source bIUreactor democratizes 3D tissue research by providing an accessible and versatile platform.
This initiative aims to accelerate the pace and scale of biomedical discoveries utilizing 3D tissue models.