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Magnetic Resonance Imaging01:24

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
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Native myocardial T1 mapping using inversion recovery T1-weighted turbo field echo sequence.

Katsuhiro Kida1, Takamasa Kurosaki2, Ryohei Fukui3

  • 1Department of Radiological Technology, Faculty of Health Sciences, Okayama University, 2-5-1 Shikata-Cho, Kita-Ku, Okayama-Shi, Okayama, 700-8558, Japan. kida-katsu@okayama-u.ac.jp.

Radiological Physics and Technology
|March 27, 2024
PubMed
Summary

The inversion recovery T1-weighted turbo field echo (IR-T1TFE) sequence offers accurate and reproducible myocardial T1 mapping. This method demonstrates high utility and validity compared to the modified Look-Locker inversion recovery (MOLLI) sequence.

Keywords:
Inversion recovery T 1-weighted turbo field echoLook-Locker inversion recoveryMagnetic resonance imagingMyocardial T 1 mapping

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Area of Science:

  • Cardiovascular Magnetic Resonance Imaging
  • Quantitative MRI Techniques

Background:

  • Myocardial T1 mapping is crucial for assessing tissue characteristics.
  • The modified Look-Locker inversion recovery (MOLLI) sequence is widely used but has limitations.
  • Accurate and reproducible T1 measurements are essential for clinical applications.

Purpose of the Study:

  • To evaluate the inversion recovery T1-weighted turbo field echo (IR-T1TFE) sequence for myocardial T1 mapping.
  • To compare the accuracy, precision, and reproducibility of IR-T1TFE with the MOLLI sequence.
  • To validate IR-T1TFE as a reliable method for native myocardial T1 quantification.

Main Methods:

  • Phantom studies were conducted using vials with known T1 values to compare IR-T1TFE, MOLLI, and inversion recovery spin-echo (IR-SE).
  • In vivo studies involved 15 healthy subjects undergoing native myocardial T1 mapping with both MOLLI and IR-T1TFE sequences.
  • Myocardium segmentation was performed to calculate whole-myocardium T1 values.

Main Results:

  • IR-T1TFE demonstrated excellent accuracy across all T1 ranges in phantom studies.
  • MOLLI showed lower accuracy than IR-T1TFE, significantly underestimating T1 values above 1000 ms.
  • In vivo, mean myocardial T1 values were higher with IR-T1TFE (1484 ± 28 ms) compared to MOLLI (1306 ± 70 ms).
  • Reproducibility within each sequence was not statistically significant.

Conclusions:

  • The IR-T1TFE sequence is a valid and useful tool for myocardial T1 mapping.
  • IR-T1TFE provides highly accurate and reproducible native myocardial T1 measurements.
  • This sequence offers a reliable alternative for quantitative assessment of myocardial tissue.