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Updated: Jun 29, 2025

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function
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A decrease in integrin α5β1/FAK is associated with increased apoptosis of aortic smooth muscle cells in acute type a

Mingming Xue1, Lingyu Xing1, Yilin Yang1

  • 1Department of Emergency Medicine, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.

BMC Cardiovascular Disorders
|March 27, 2024
PubMed
Summary

Integrin α5β1 and FAK levels decrease in acute type A aortic dissection (AAAD), leading to increased smooth muscle cell apoptosis. Restoring these factors may offer a therapeutic strategy for AAAD.

Keywords:
Acute type a aortic dissectionApoptosisHuman aortic smooth cellIntegrin α5β

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