Clinical significance of postoperative folate receptor-positive circulating tumor cells (FR + CTCs) for long-term prognosis in patients with invasive adenocarcinoma (IAC) of the lung
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View abstract on PubMed
Summary
This summary is machine-generated.Postoperative detection of folate receptor-positive circulating tumor cells (FR+) CTCs is an independent predictor of recurrence in patients with invasive adenocarcinoma (IAC). Further studies are needed to standardize FR+ CTC detection methods.
Area Of Science
- Oncology
- Molecular Diagnostics
- Cancer Biomarkers
Background
- Investigating the prognostic significance of postoperative folate receptor-positive circulating tumor cells (FR+ CTCs) in patients with stage I-III invasive adenocarcinoma (IAC) undergoing surgical treatment.
- Lung adenocarcinoma (LUAD) patients treated surgically between July 2016 and January 2021 at Peking University Cancer Hospital were retrospectively analyzed.
Purpose Of The Study
- To evaluate the prognostic value of FR+ CTC detection after surgery in patients with stage I-III invasive adenocarcinoma (IAC).
- To identify independent predictors of disease recurrence and survival in these patients.
Main Methods
- Retrospective collection of LUAD patients who had undergone surgical resection and postoperative FR+ CTC analysis.
- Statistical analyses included Kruskal-Wallis, Mann-Whitney U tests, Kaplan-Meier survival analysis, log-rank tests, and Cox proportional hazard regression.
- Exploration of factors predicting recurrence and survival, including N stage, neoadjuvant therapy, pleural invasion, and nerve invasion.
Main Results
- Significant differences observed between high and low FR+ CTC groups in age, postoperative CA199, and SCC (p < 0.05).
- N stage 1, N stage 2, and neoadjuvant therapy (NAT) were identified as independent risk factors for recurrence and death.
- Pleural invasion (PI) and nerve invasion were independent risk factors for death. A trend towards worse disease-free survival (DFS) and overall survival (OS) was noted in patients with high FR+ CTC levels, though not statistically significant.
Conclusions
- Postoperative FR+ CTC detection serves as an independent predictor of recurrence in stage I-III IAC patients.
- Standardization of detection methods and determination of optimal assessment time points for FR+ CTCs are crucial for future research.
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