Related Experiment Video
Updated: Jun 29, 2025
08:51
A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies
Published on: March 8, 2014
16.7K
Gelatinous bone marrow with vivid fatty cells
Osamu Imataki1, Makiko Uemura1
1Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan.
Oxford Medical Case Reports
|March 27, 2024
Summary
This study reports a rare case of gelatinous bone marrow in a patient treated for gastric lymphoma. CD68 staining of atrophic fatty tissue in bone marrow may serve as a novel diagnostic marker.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Gastric diffuse large B cell lymphoma (DLBCL) is a significant hematologic malignancy.
- Treatment often involves chemotherapy and radiation therapy.
- Long-term complications of cancer treatment require careful monitoring.
Observation:
- A 78-year-old man developed anorexia and pancytopenia three years post-treatment for gastric DLBCL.
- Bone marrow examination revealed focal eosinophilic deposits with atrophic fatty cells.
- These findings were pathologically diagnosed as gelatinous bone marrow.
Findings:
- The patient's gelatinous bone marrow exhibited characteristic CD68-stained atrophic fatty tissue.
- This histological feature is proposed as a potential alternative diagnostic marker for gelatinous bone marrow.
- Normal levels of vitamin B12, folate, zinc, and copper ruled out nutritional deficiencies.
Implications:
- This case highlights a rare bone marrow finding potentially associated with prior cancer therapy.
- CD68 staining may offer a valuable diagnostic clue for gelatinous bone marrow.
- Further research is warranted to understand the pathogenesis and clinical significance of this condition.
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