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Cushing's syndrome during pregnancy - two case reports
Sumita Cholekho1, Yuke Liu1, Huiwen Tan1
1Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in Endocrinology
|March 27, 2024
Summary
Cushing's syndrome in pregnancy is rare but risky. Early diagnosis and expert management are crucial to reduce maternal and fetal complications.
Area of Science:
- Endocrinology
- Obstetrics
- Reproductive Medicine
Background:
- Cushing's syndrome (CS) in pregnancy, marked by hypercortisolism, presents a rare but significant risk for maternal and fetal complications.
- This case study aims to refine diagnostic and therapeutic strategies for CS during pregnancy to mitigate adverse outcomes.
Observation:
- Two pregnant patients with CS, including one with twins, presented with classic hypercortisolism symptoms early in pregnancy.
- Diagnostic confirmation involved assessing plasma cortisol diurnal rhythm, cortisol and ACTH levels, and imaging studies.
Findings:
- The study investigated the hypothalamic-pituitary-adrenal axis in normal pregnancy and explored the etiology, diagnosis, and treatment of CS during gestation.
- Laparoscopic adrenalectomy's efficacy in reducing maternal mortality in pregnant CS patients remains uncertain, necessitating further research.
Implications:
- Accurate diagnosis and timely management of CS in pregnancy are vital for improving maternal and fetal outcomes.
- Management requires multidisciplinary expertise and should occur in specialized centers to minimize risks associated with this rare condition.
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