Predictive value of procollagen c-protease enhancer protein on the prognosis of glioma patients
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Procollagen c-protease enhancer protein (PCOLCE) is elevated in glioma and linked to poor prognosis. PCOLCE influences immune cell infiltration and may regulate tumor development via immune pathways, impacting treatment response.
Area Of Science
- Oncology
- Immunology
- Bioinformatics
Background
- Procollagen c-protease enhancer protein (PCOLCE) is crucial for extracellular matrix reconstruction.
- High PCOLCE expression correlates with poor prognosis in stomach cancer, ovarian cancer, and osteosarcoma.
Purpose Of The Study
- To investigate the role and function of PCOLCE in glioma.
- To analyze the association of PCOLCE with prognosis, immune checkpoints, and the tumor microenvironment in glioma.
Main Methods
- Utilized multiple bioinformatics techniques to analyze PCOLCE expression and its correlations.
- Performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.
- Assessed PCOLCE's relationship with prognosis, tumor grade, immune cell infiltration, and immune checkpoints.
Main Results
- PCOLCE expression is increased in glioma and associated with poor prognosis in lower-grade glioma (LGG), glioblastoma multiforme (GBM), and recurrent glioma.
- PCOLCE correlates with infiltration of B cells, CD4+ T cells, macrophages, neutrophils, and dendritic cells (DCs) in LGG, and DCs in GBM.
- PCOLCE co-expresses with immune-related genes and immune checkpoints; low PCOLCE expression predicts better response to immunological checkpoint blockade (ICB).
Conclusions
- PCOLCE is a potential prognostic factor in glioma, linked to tumor grade and progression.
- PCOLCE influences the glioma immune microenvironment and may regulate tumor development through immune-related pathways.
- PCOLCE represents a potential novel immune-related target for glioma therapy.
These videos have been matched automatically. Contact us if they are not relevant.
These videos have been matched automatically. Contact us if they are not relevant.