Related Experiment Video

Updated: Jun 29, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

Published on: July 29, 2014

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Progress in the study of intestinal microbiota involved in morphine tolerance

Ke Bi1,2, Yi Lei1, Deshenyue Kong1,2

  • 1Department of Gastrointestinal and Hernia Surgery, First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.

Heliyon
|March 27, 2024
PubMed

Insights

Morphine tolerance is linked to gut microbiota changes. This study explores how gut microbes influence morphine tolerance and potential therapeutic strategies targeting the gut microbiota-brain axis.

Area of Science:

  • Pharmacology
  • Microbiology
  • Neuroscience

Background:

  • Morphine is a key pain reliever, but tolerance and dependence are significant public health issues.
  • The gut microbiota plays a role in various physiological and pathophysiological processes.
  • Bidirectional communication within the microbiota-gut-brain axis is crucial for homeostasis.

Purpose of the Study:

  • To review mechanisms of morphine tolerance from the perspective of microbiota-gut-brain axis dysregulation.
  • To summarize gut-derived mechanisms affecting morphine tolerance.
  • To explore the potential of gut microbiota modulation for improving morphine tolerance.

Main Methods:

  • Literature review of existing research on morphine tolerance and gut microbiota.
  • Analysis of studies investigating the effects of morphine on the gastrointestinal tract.
  • Synthesis of findings related to the microbiota-gut-brain axis and opioid tolerance.

Main Results:

  • Morphine affects the gastrointestinal tract, but the role of intestinal microbiota in tolerance was previously undetermined.
  • Dysregulation of the microbiota-gut-brain axis is implicated in morphine tolerance.
  • Gut microbiota alterations may contribute to the development of morphine tolerance.

Conclusions:

  • The gut microbiota is a potential factor influencing morphine tolerance.
  • Targeting the gut microbiota may offer novel strategies for managing morphine tolerance.
  • Further research is needed to elucidate the precise mechanisms and therapeutic potential.
Keywords:
Gut- brain axisIntestinal microbiotaMorphine tolerancePro-inflammatory cytokineProbiotic

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