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Impact And Prevalence Of Comorbidities And Complications On The Severity Of Covid-19 In Association With Age, Gender, Obesity, And Pre-existing Smoking: A Meta-analysis.

Home
Research Domains
Biomedical And Clinical Sciences
Oncology And Carcinogenesis
Predictive And Prognostic Markers
Impact And Prevalence Of Comorbidities And Complications On The Severity Of Covid-19 In Association With Age, Gender, Obesity, And Pre-existing Smoking: A Meta-analysis.

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Impact and prevalence of comorbidities and complications on the severity of COVID-19 in association with age, gender, obesity, and pre-existing smoking: A meta-analysis.

Soulandi Djorwé^1,2, Amale Bousfiha¹, Néhémie Nzoyikorera^3,4,5

¹Laboratory of Physiopathology and Molecular Genetics, Faculty of Sciences Ben M'Sik, Hassan II University of Casablanca (Morocco), Avenue Cdt Driss El Harti, PB 7955, Sidi Othman, Casablanca, Morocco.

|March 27, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Keywords:

Comorbidities Complications Non-severe COVID-19 Risk factors

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Male gender, advanced age, smoking, obesity, diabetes, hypertension, and cardiovascular diseases significantly increase the risk of severe COVID-19. These comorbidities and complications hinder recovery, highlighting the need for better management.

Area of Science:

Infectious Diseases
Epidemiology
Public Health

Background:

COVID-19 (Coronavirus Disease 2019) often presents with multiple comorbidities and complications.
These factors are frequently associated with severe forms of SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection.

Purpose of the Study:

To assess the risk factors and prevalence of comorbidities and complications contributing to COVID-19 severity.
To identify key indicators associated with severe disease outcomes.

Main Methods:

A meta-analysis was conducted following PRISMA guidelines.
Searched databases including PubMed, Google Scholar, and Scopus from 2020 to 2023.
Included 33 studies encompassing 85,812 patients.

Severe COVID-19

Main Results:

36% of patients experienced severe COVID-19.
Severe disease correlated with male gender, advanced age, smoking, obesity, diabetes, hypertension, coronary heart disease, CKD, COPD, malignancy, and cerebrovascular disease.
Severe complications included shock, ARDS (Acute Respiratory Distress Syndrome), AKI (Acute Kidney Injury), and arrhythmia, hindering recovery.

Conclusions:

Identified comorbidities and complications significantly increase COVID-19 severity and impede patient recovery.
These factors represent critical risk factors that require management to mitigate adverse outcomes.