Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age and Procedural Timing for Asymptomatic Severe Aortic Stenosis: Analysis From the EARLY TAVR Trial.

Circulation. Cardiovascular interventions·2026
Same author

Five-Year Outcomes for Patients With RVOT Dysfunction Treated With the SAPIEN 3 Transcatheter Heart Valve: A Pooled Analysis From the COMPASSION S3 Trial.

Circulation. Cardiovascular interventions·2026
Same author

Low Contrast Photon-Counting Detector CT Using Spectral Information to Enhance Structural Heart Intervention Planning.

Circulation. Cardiovascular imaging·2026
Same author

Transcatheter Pulmonary Valve Implantation With the Alterra Adaptive Prestent and SAPIEN 3 Transcatheter Heart Valve: 3-Year Pooled Outcomes of the ALTERRA Trials.

Circulation. Cardiovascular interventions·2026
Same author

Hemodynamics and Mid-Term Clinical Outcomes Following Valve-in-Valve TAVR With Balloon-Expandable Valves.

Circulation. Cardiovascular interventions·2026
Same author

Fatal Steam Pop Complicating Investigational SESAME Transcatheter Myotomy Using Off-the-Shelf Equipment.

Circulation. Cardiovascular interventions·2026
Same journal

Risk of Aortic Root Rupture in Bicuspid Aortic Stenosis: The ABC Sizing Algorithm for SAPIEN 3 Valves.

Circulation. Cardiovascular interventions·2026
Same journal

Transcatheter Mitral Valve-in-Valve: Optimal Sizing and Expansion Matter.

Circulation. Cardiovascular interventions·2026
Same journal

Nicorandil to Prevent Contrast-Associated Kidney Injury in High-Risk PCI.

Circulation. Cardiovascular interventions·2026
Same journal

Prospective Midterm Outcomes of the PULSTA Self-Expandable Transcatheter Pulmonary Valve: The PULSTA CE Approval Study.

Circulation. Cardiovascular interventions·2026
Same journal

Is There a Golden Hour for Thrombectomy in Intermediate-Risk Pulmonary Embolism? Insights From SYMPHONY-PE.

Circulation. Cardiovascular interventions·2026
Same journal

Seeing More With Less: AI to Reduce Radiation Exposure in the Cath Lab.

Circulation. Cardiovascular interventions·2026
See all related articles

Related Experiment Video

Updated: Jun 29, 2025

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion
10:27

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Published on: December 10, 2020

3.5K

TABERNACL: Temporary Hemodynamic Stabilization In Vivo.

Rim N Halaby1, Christopher G Bruce2, D Korel Yildirim1

  • 1Cardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD (R.H., K.Y., D.U., A.E.J., L.P.G., R.J.L.).

Circulation. Cardiovascular Interventions
|March 27, 2024
PubMed
Summary
This summary is machine-generated.

A novel Trans-Aortic Balloon to Ease Regurgitation Applying Counter-Pulsation (TABERNACL) device effectively stabilizes hemodynamics in acute aortic regurgitation. This temporary valve shows promise as a life-saving bridge to definitive treatment in animal models.

Keywords:
angioplastyanimalsaortic valve insufficiencycathetersfatigue

More Related Videos

Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

12.5K
Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
07:51

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

7.4K

Related Experiment Videos

Last Updated: Jun 29, 2025

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion
10:27

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Published on: December 10, 2020

3.5K
Integrated Compensatory Responses in a Human Model of Hemorrhage
07:57

Integrated Compensatory Responses in a Human Model of Hemorrhage

Published on: November 20, 2016

12.5K
Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs
07:51

Standardized Hemorrhagic Shock Induction Guided by Cerebral Oximetry and Extended Hemodynamic Monitoring in Pigs

Published on: May 21, 2019

7.4K

Area of Science:

  • Cardiovascular Surgery
  • Medical Devices
  • Interventional Cardiology

Background:

  • Acute aortic regurgitation presents a life-threatening emergency with limited nonsurgical stabilization options.
  • A novel temporary valve, Trans-Aortic Balloon to Ease Regurgitation Applying Counter-Pulsation (TABERNACL), is proposed for immediate hemodynamic stabilization.
  • TABERNACL utilizes readily available commercial equipment for on-table application.

Purpose of the Study:

  • To evaluate the efficacy of a commercial balloon dilatation catheter as a temporizing valve for acute severe aortic regurgitation.
  • To assess the ability of TABERNACL to restore hemodynamic stability in a porcine model.
  • To compare TABERNACL with a static balloon inflation technique.

Main Methods:

  • Benchtop testing of various balloon catheters for suitability as temporary valves.
  • In vivo assessment of TABERNACL in a porcine model (n=8) of acute aortic regurgitation.
  • Evaluation of a static undersized transvalvular balloon as an alternative method.

Main Results:

  • Specific balloon catheters demonstrated adequate performance and fatigue resistance in benchtop tests.
  • TABERNACL use in animals resulted in immediate hemodynamic improvement, including increased diastolic aortic pressure and improved aortic diastolic index.
  • Significant reductions in left ventricular end-diastolic pressure and reversal of electrocardiographic myocardial ischemia were observed.

Conclusions:

  • TABERNACL effectively improves hemodynamics and reduces myocardial ischemia in acute severe aortic regurgitation in an animal model.
  • The device functions by obstructing the diastolic regurgitant orifice without causing systolic obstruction.
  • TABERNACL represents a potential life-saving bridge to definitive aortic valve replacement therapy.