Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dose-Response Relationship: Potency and Efficacy01:22

Dose-Response Relationship: Potency and Efficacy

The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it produces...
Drug-Receptor Interaction: Antagonist01:28

Drug-Receptor Interaction: Antagonist

An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
Antagonists can be classified as competitive or noncompetitive based on their...
Quantitative Aspects of Drug-Receptor Interaction01:30

Quantitative Aspects of Drug-Receptor Interaction

The receptor occupancy theory connects a drug's response to the number of occupied receptors. With higher drug concentrations, more receptors are occupied, leading to increased responses. The formation of drug-receptor complexes involves association and dissociation rates, which reach equilibrium when the forward and backward reactions are equal. The equilibrium association constant (Ka) and its inverse, the equilibrium dissociation constant (Kd), indicate drug affinity. Higher Ka and lower Kd...
Agonism and Antagonism: Quantification01:14

Agonism and Antagonism: Quantification

When drugs are administered, they can elicit either an agonist or antagonist effect on the body. Agonism occurs when a drug activates a specific receptor, triggering a biological response. On the other hand, antagonism happens when a drug binds to the same receptors but blocks their activation, thereby preventing a biological response.
To quantify these effects, researchers use a dose-response curve, which provides valuable information about the potency and efficacy of a drug. Potency refers to...
Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
Ophthalmic Drug Delivery Systems01:23

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Breathing bad: increased risk for obstructive sleep apnea in current and former smokers.

Scientific reports·2026
Same author

Sex differences in obstructive sleep apnea: a population-based study from northeastern Germany.

Sleep & breathing = Schlaf & Atmung·2026
Same author

Digital occlusion and occlusal analysis - a positioning.

International journal of computerized dentistry·2025
Same author

Distribution patterns of occlusal contact areas on natural posterior teeth - Evaluations of a cross-sectional population-based study with the Greifswald Digital Analyzing System (GEDAS).

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2023
Same author

Number and localization of occlusal contact areas on natural posterior teeth without dental findings - evaluations of the regional baseline study (SHIP-1) with the Greifswald Digital Analyzing System (GEDAS).

International journal of computerized dentistry·2022
Same author

Validation of digital analysis of occlusion in primary and mixed dentition using GEDAS.

International journal of computerized dentistry·2021

Related Experiment Video

Updated: May 10, 2026

Shrinkage of Dental Composite in Simulated Cavity Measured with Digital Image Correlation
08:45

Shrinkage of Dental Composite in Simulated Cavity Measured with Digital Image Correlation

Published on: July 21, 2014

13.5K

Comparing Zirconium Crown Marginal Adaptation in Preparations with Two Different Occlusal Reductions.

Ali Khekan1, Bernd Kordaß1

  • 1Department of Prosthodontics, Faculty of Dentistry, Greifswald University, 17489 Greifswald, Germany.

Dentistry Journal
|March 27, 2024
PubMed
Summary

A planar occlusal reduction scheme with a chamfer finish line provides superior vertical marginal fit for monolithic zirconia crowns compared to a flat scheme. This finding aids in selecting optimal dental restoration techniques.

Keywords:
marginal fitnessocclusal reduction schemeresin-modified glass ionomer cementzirconia

More Related Videos

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment
07:32

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment

Published on: February 23, 2024

1.1K
Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material
07:42

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material

Published on: December 20, 2024

375

Related Experiment Videos

Last Updated: May 10, 2026

Shrinkage of Dental Composite in Simulated Cavity Measured with Digital Image Correlation
08:45

Shrinkage of Dental Composite in Simulated Cavity Measured with Digital Image Correlation

Published on: July 21, 2014

13.5K
Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment
07:32

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment

Published on: February 23, 2024

1.1K
Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material
07:42

Quasistatic Mechanical Testing for Computer-Aided Design and Manufacturing Occlusal Veneers Cemented to Milled Dentin Analog Material

Published on: December 20, 2024

375

Area of Science:

  • Dental Materials Science
  • Prosthodontics
  • Biomaterials Engineering

Background:

  • Accurate marginal fit of dental restorations is crucial for long-term success.
  • Monolithic zirconia crowns fabricated with CAD/CAM offer improved aesthetics and strength.
  • Various occlusal reduction schemes and cements can influence the marginal integrity of crowns.

Purpose of the Study:

  • To evaluate the vertical marginal fit of CAD/CAM monolithic zirconia crowns.
  • To compare the effects of planar versus flat occlusal reduction schemes.
  • To assess the impact of different cements on marginal fit before and after cementation.

Main Methods:

  • Forty maxillary first premolars were prepared with chamfer finishing lines.
  • Two occlusal reduction schemes (planar and flat) were employed.
  • Crowns were cemented using resin-modified glass ionomer cement or a universal adhesive system.
  • Vertical marginal gap was measured using a stereomicroscope pre- and post-cementation.

Main Results:

  • Subgroup A1 (planar reduction, resin-modified glass ionomer cement) exhibited the lowest mean vertical marginal gap pre- and post-cementation.
  • Subgroup B2 (flat reduction, universal adhesive system) showed the highest mean vertical marginal gap.
  • The planar occlusal reduction scheme generally resulted in better marginal fit.

Conclusions:

  • A chamfer finishing line design with a planar occlusal reduction scheme is preferable for monolithic zirconia crowns.
  • The choice of occlusal reduction scheme significantly impacts the vertical marginal fit.
  • This study provides valuable insights for optimizing dental crown fabrication and cementation protocols.