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Published on: February 23, 2020
Stress Load and Ascending Aortic Aneurysms: An Observational, Longitudinal, Single-Center Study Using Computational
Fabiula Schwartz de Azevedo1,2, Gabriela de Castro Almeida3, Bruno Alvares de Azevedo3
1Department of Cardiology, Federal University of Rio de Janeiro, Rio de Janeiro 21941-913, RJ, Brazil.
High pressure and wall shear stress in ascending aortic aneurysms (AAoA) are linked to disease growth. Computational fluid dynamics revealed these hemodynamic factors predict a worse prognosis for AAoA.
Area of Science:
- Cardiovascular Medicine
- Biomedical Engineering
- Medical Imaging
Background:
- Ascending aortic aneurysm (AAoA) is a significant cause of mortality.
- Prognostic factors for AAoA progression remain incompletely understood.
- Understanding mechanobiology is crucial for AAoA progression.
Purpose of the Study:
- To identify hemodynamic patterns influencing AAoA growth.
- To investigate the impact of geometrical variations on aortic hemodynamics.
- To correlate hemodynamic parameters with aneurysm expansion.
Main Methods:
- Observational, longitudinal, single-center study.
- Utilized computational fluid dynamics (CFD) on personalized aortic models from angiotomography scans.
- Analyzed 30 patients over 1-3 year intervals, assessing aneurysm volume changes.
Main Results:
- Hemodynamic factors associated with AAoA growth identified.
- High average/maximum pressure (>100 Pa) correlated with growth.
- High wall shear stress (>7 Pa) combined with high pressure, and stress load over time also predicted growth.
Conclusions:
- Hemodynamic patterns, including pressure and wall shear stress, are key indicators of AAoA progression.
- CFD analysis provides valuable insights into AAoA mechanobiology.
- Findings may contribute to improved prognosis prediction for ascending aortic aneurysms.
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