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Related Concept Videos

Surface Active Agents01:27

Surface Active Agents

158
Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
158

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Synthesis of PolyN-isopropylacrylamide Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability
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Anti-UV Microgel Based on Interfacial Polymerization to Decrease Skin Irritation of High Permeability UV Absorber

Wei Wang1,2, Qi-Tong He1, Yin-Feng Chen1

  • 1School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China.

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|March 27, 2024
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Summary

This study developed a novel microgel carrier for Ethylhexyl methoxycinnamate (EHMC) sunscreen ingredient. The new formulation effectively reduces skin irritation and penetration while maintaining UV protection.

Keywords:
EHMCmicrogelpolymerizationskin irritationsunscreen

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Area of Science:

  • Materials Science
  • Dermatology
  • Polymer Chemistry

Background:

  • Ethylhexyl methoxycinnamate (EHMC) is a common UV filter in sunscreens.
  • EHMC can cause skin irritation and penetrate the skin, raising health concerns.

Purpose of the Study:

  • To synthesize a microgel carrier (pEDGMA) for EHMC.
  • To reduce EHMC's skin irritation and penetration while preserving its UV-protective properties.

Main Methods:

  • Interfacial polymerization was used to create poly(ethylene glycol dimethacrylate) (pEDGMA) microgels.
  • Thermogravimetric analysis (TGA) quantified EHMC content.
  • Scanning electron microscopy (SEM) analyzed microgel morphology.
  • FTIR and contact angle tests confirmed EHMC loading.
  • UV resistance, skin penetration, and irritation tests were performed.

Main Results:

  • The microgel carrier (pEDGMA) successfully encapsulated EHMC.
  • Thermogravimetric analysis showed EHMC constituted 75.72% of the microgel.
  • SEM images confirmed a spherical microgel morphology.
  • The EHMC-loaded microgel exhibited limited dermal absorption.
  • No skin irritation was observed with the novel formulation.

Conclusions:

  • The developed EHMC-pEDGMA microgel offers a safer alternative for sunscreen formulations.
  • This microgel effectively reduces skin irritation and dermal absorption of EHMC.
  • The formulation provides adequate UV protection.