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Designing Silk-silk Protein Alloy Materials for Biomedical Applications
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pH-Responsive Cellulose/Silk/Fe3O4 Hydrogel Microbeads Designed for Biomedical Applications.

Seung Hyeon Weon1, Yuhyeon Na1, Jiwoo Han1

  • 1Department of Biological Engineering, Konkuk University, Seoul 05029, Republic of Korea.

Gels (Basel, Switzerland)
|March 27, 2024
PubMed
Summary

New cellulose/silk/Fe3O4 hydrogel microbeads offer enhanced adsorption for dyes and proteins. These biocompatible, pH-responsive materials show promise as supports for oral protein drug delivery systems.

Keywords:
cellulosemicrobeadpH responsiveprotein supportsilk

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Area of Science:

  • Materials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Cellulose-based hydrogels are explored for drug delivery applications.
  • Magnetic nanoparticles (Fe3O4) can enhance hydrogel properties.
  • Protein drug delivery requires carriers with specific adsorption and release characteristics.

Purpose of the Study:

  • To develop novel cellulose/Fe3O4 and cellulose/silk/Fe3O4 hydrogel microbeads.
  • To investigate the adsorption capabilities of these microbeads for dyes and proteins.
  • To evaluate the pH-responsive release of proteins and the biocompatibility of the materials.

Main Methods:

  • Sol-gel transition of oil-in-water emulsion using cellulose-dissolving solvents (tetrabutylammonium hydroxide/tetrabutylphosphonium hydroxide) and soybean oil.
  • Incorporation of Fe3O4 nanoparticles and silk protein.
  • Characterization of microbead properties, adsorption capacity (crystal violet, bovine serum albumin), and pH-dependent release kinetics.
  • Cytotoxicity assessment.

Main Results:

  • Cellulose/Fe3O4 and cellulose/silk/Fe3O4 microbeads (~15 µm) were successfully prepared without surfactants.
  • Cellulose/silk/Fe3O4 microbeads exhibited >10x higher crystal violet adsorption than cellulose/Fe3O4 microbeads.
  • Significantly enhanced initial and equilibrium adsorption rates for bovine serum albumin (BSA) were observed with cellulose/silk/Fe3O4 microbeads.
  • pH-dependent BSA release demonstrated slower desorption at acidic pH.
  • Cytotoxicity tests confirmed the materials are nontoxic.

Conclusions:

  • Cellulose/silk/Fe3O4 hydrogel microbeads are effective adsorbents for dyes and proteins.
  • The developed microbeads demonstrate pH-responsive drug release properties.
  • These biocompatible materials are suitable as supports for orally administered protein pharmaceuticals.