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Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
COVID-19 Associated Cardiovascular Disease-Risks, Prevention and Management: Heart at Risk Due to COVID-19
Andrew Kemerley1, Abhishek Gupta1, Mahesh Thirunavukkarasu1
1Department of Surgery, Molecular Cardiology and Angiogenesis Laboratory, University of Connecticut School of Medicine, UConn Health, 263 Farmington Avenue, Farmington, CT 06030, USA.
Insights
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) impacts the cardiovascular system, causing complications like myocarditis and cardiac failure. This review explores COVID-19
Area of Science:
- Cardiology
- Infectious Diseases
- Virology
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, has widespread health implications beyond the respiratory system.
- Cardiovascular complications are increasingly recognized in COVID-19 patients, affecting both adults and children.
- Pre-existing conditions like hypertension and diabetes exacerbate cardiovascular risks associated with COVID-19.
Purpose of the Study:
- To review the cardiovascular effects of SARS-CoV-2 infection.
- To discuss the mechanisms, clinical presentation, and diagnostic findings of COVID-19-related cardiovascular complications.
- To explore current and evolving treatment and prevention strategies for these complications.
Main Methods:
- Literature review of clinical outcomes, research findings, and case reports on SARS-CoV-2 and the cardiovascular system.
- Analysis of documented cardiovascular complications, including hyperinflammatory syndrome, myocarditis, and cardiac failure.
- Examination of diagnostic approaches and therapeutic interventions for managing cardiovascular manifestations of COVID-19.
Main Results:
- COVID-19 infection can lead to significant cardiovascular complications, such as myocarditis and heart failure, even in individuals without prior cardiovascular disease.
- Pediatric populations are susceptible to systemic complications like multisystem inflammatory syndrome in children (MIS-C).
- SARS-CoV-2 contributes to an inflammatory environment that negatively impacts cardiovascular health.
Conclusions:
- Understanding the mechanisms by which SARS-CoV-2 affects the cardiovascular system is crucial for effective patient management.
- Prompt diagnosis and tailored treatment strategies are essential for improving outcomes in patients with COVID-19-related cardiovascular complications.
- Further research is needed to fully elucidate the complex interplay between SARS-CoV-2 and cardiovascular physiology.
Abstract:
The SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2) virus and the resulting COVID-19 pandemic have had devastating and lasting impact on the global population. Although the main target of the disease is the respiratory tract, clinical outcomes, and research have also shown significant effects of infection on other organ systems. Of interest in this review is the effect of the virus on the cardiovascular system. Complications, including hyperinflammatory syndrome, myocarditis, and cardiac failure, have been documented in the context of COVID-19 infection. These complications ultimately contribute to worse patient outcomes, especially in patients with pre-existing conditions such as hypertension, diabetes, or cardiovascular disease (CVD). Importantly and interestingly, reports have demonstrated that COVID-19 also causes myocardial injury in adults without pre-existing conditions and contributes to systemic complications in pediatric populations, such as the development of multisystem inflammatory syndrome in children (MIS-C). Although there is still a debate over the exact mechanisms by which such complications arise, understanding the potential paths by which the virus can influence the cardiovascular system to create an inflammatory environment may clarify how SARS-CoV-2 interacts with human physiology. In addition to describing the mechanisms of disease propagation and patient presentation, this review discusses the diagnostic findings and treatment strategies and the evolution of management for patients presenting with cardiovascular complications, focusing on disease treatment and prevention.
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