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Biomimicking Atherosclerotic Vessels: A Relevant and (Yet) Sub-Explored Topic
Joana Henriques1, Ana M Amaro1, Ana P Piedade1
1University of Coimbra, CEMMPRE, ARISE, Department of Mechanical Engineering, 3030-788 Coimbra, Portugal.
Biomimetics (Basel, Switzerland)
|March 27, 2024
Summary
Biomimicking physical models offer a reproducible and ethical alternative to animal testing for studying atherosclerosis. These models aid in understanding cardiovascular disease and optimizing patient-specific treatments.
Area of Science:
- Biomedical Engineering
- Cardiovascular Research
- Materials Science
Background:
- Atherosclerosis is a primary cause of global mortality, driving the need for advanced diagnostic and therapeutic strategies.
- Understanding atherosclerosis pathophysiology is crucial for developing effective interventions.
- Current research focuses on improving diagnostic and therapeutic approaches for cardiovascular diseases.
Purpose of the Study:
- To review the fabrication of biomimicking atherosclerotic models.
- To focus on the selection of tissue-mimicking materials based on intended applications.
- To highlight the utility of these models in cardiovascular research.
Main Methods:
- Review of literature on biomimicking models for atherosclerosis.
- Analysis of material selection criteria for different applications.
- Discussion of model capabilities in simulating disease states.
Main Results:
- Biomimicking models provide reproducible, cost-effective, and ethically sound alternatives to animal experimentation.
- These models can represent various atherosclerotic stages and plaque types.
- They are valuable for investigating hemodynamics, pharmacodynamics, biomechanics, and optimizing imaging.
Conclusions:
- Biomimicking models are essential tools for advancing atherosclerosis research and treatment.
- Material selection is critical and depends on the specific application of the biomodel.
- These models offer a pathway to personalized medicine for cardiovascular diseases.
