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The REthinking Clinical Trials Program Retreat 2023: Creating Partnerships to Optimize Quality Cancer Care
Ana-Alicia Beltran-Bless1,2, Mark Clemons1,2, Lisa Vandermeer2
1Department of Medicine, Division of Medical Oncology, The Ottawa Hospital, University of Ottawa, Ottawa, ON K1H 8L6, Canada.
Current Oncology (Toronto, Ont.)
|March 27, 2024
Summary
The REthinking Clinical Trials (REaCT) program aims to improve healthcare quality by addressing barriers in clinical trials. Innovations like AI and near equivalence analyses are key to maximizing trial impact and informing treatment decisions.
Area of Science:
- Clinical trial methodology
- Health services research
Background:
- Patients and providers lack clear guidance on optimal treatment choices, impacting healthcare quality.
- Traditional clinical trials face barriers hindering their effectiveness and widespread adoption.
Framework:
- The REthinking Clinical Trials (REaCT) program, initiated in 2014, seeks to overcome traditional clinical trial limitations.
- Integration of innovative methodologies is crucial for enhancing the impact of pragmatic trials.
Implementation:
- Near equivalence analyses enable comprehensive treatment comparisons using diverse data types (QoL, cost, PK/PD).
- Artificial intelligence (AI) can optimize clinical trial design, reduce sample sizes, and improve trial accrual.
- The first REaCT international symposium convened experts to foster collaboration and define future directions for investigator-led trials.
Implications:
- Wider adoption of innovative methods like AI and near equivalence analyses is essential for advancing clinical trial science.
- Sharing experiences from initiatives like REaCT can accelerate progress in conducting impactful, patient-centered clinical research.
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