Related Experiment Video
Updated: Jun 29, 2025
04:04
Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
Published on: February 12, 2017
10.5K
Pulmonary Adverse Events in Cancer Immunotherapy: Case Studies of CT Patterns
Giorgio Bocchini1, Maria Chiara Imperato2, Tullio Valente1
1Department of Radiology, Monaldi Hospital, Azienda Ospedaliera dei Colli, 80131 Naples, Italy.
Diagnostics (Basel, Switzerland)
|March 27, 2024
Summary
Immune-checkpoint inhibitors improve cancer treatment but can cause immune-related adverse events. Early diagnosis of lung complications is crucial for patient management.
Area of Science:
- Oncology
- Immunology
- Radiology
Background:
- Immune-checkpoint inhibitors (ICIs) have revolutionized cancer therapy.
- ICI therapy activates the immune system, leading to immune-related adverse events (irAEs) affecting various organs.
- Pulmonary irAEs are common and can be severe.
Purpose of the Study:
- To highlight the diagnostic challenges of pulmonary irAEs.
- To emphasize the critical role of radiologists in early detection and management of pulmonary irAEs.
Main Methods:
- Review of clinical and radiological findings in pulmonary irAEs.
- Discussion of diagnostic criteria and imaging features.
Main Results:
- Pulmonary irAEs present with diverse and non-specific clinical and radiological manifestations.
- Early recognition by radiologists is key to timely intervention.
Conclusions:
- Radiologists play a vital role in diagnosing pulmonary irAEs.
- Accurate and early diagnosis aids in guiding patient management and improving outcomes.
Keywords:
hypersensitivity pneumonitisimmune-checkpoint inhibitorsimmune-related adverse eventslung toxicitynon-specific interstitial pneumoniaorganizing pneumoniasarcoid-like reactionMore Related Videos
Related Concept Videos
01:27Tumor Immunotherapy
523
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
523
01:17Other Pulmonary Disorders
837
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
837
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K