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Updated: Apr 30, 2026

Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
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Left Ventricular Diastolic Dysfunction Is Associated with Poor Functional Outcomes after Endovascular Thrombectomy

Tony Y W Li1, Emma M S Toh2, Ying Ying Koh2

  • 1Department of Cardiology, National University Heart Centre Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, Singapore 119228, Singapore.

Journal of Cardiovascular Development and Disease
|March 27, 2024
PubMed

Insights

Left ventricular diastolic dysfunction (LVDD) is linked to worse functional recovery in acute ischemic stroke patients undergoing endovascular thrombectomy (ET). LVDD did not significantly impact in-hospital mortality in this study. Further research is recommended.

Area of Science:

  • Cardiology
  • Neurology
  • Stroke Medicine

Background:

  • Endovascular thrombectomy (ET) has improved outcomes for acute ischemic stroke (AIS) with large vessel occlusion (LVO).
  • Left ventricular diastolic dysfunction (LVDD) is associated with poor prognosis in other cardiovascular conditions.
  • The impact of LVDD on functional recovery after stroke remains unclear.

Purpose of the Study:

  • To investigate the relationship between LVDD and clinical outcomes in patients with LVO AIS who underwent ET.
  • To assess the association of LVDD with short-term mortality and functional recovery.

Main Methods:

  • Retrospective cohort study of 261 LVO AIS patients who underwent ET.
  • Correlation of LVDD with in-hospital mortality and modified Rankin Scale (mRS) score at 3 months (0-2 for good recovery).

Main Results:

  • LVDD was present in 31.4% of patients.
  • LVDD was associated with poorer functional recovery at 3 months (OR 2.18, 95% CI 1.04-4.54, p=0.038).
  • LVDD was not significantly associated with increased in-hospital mortality (OR 2.18, 95% CI 0.60-7.99, p=0.240) after adjustment.

Conclusions:

  • LVDD may indicate poorer outcomes in patients undergoing ET for LVO AIS, beyond traditional echocardiographic measures.
  • Further investigation into the role of LVDD in stroke recovery is warranted.
Abstract

Keywords:
atrial fibrillationcerebrovascular diseasediastolic dysfunctionembolismischaemic strokestroke

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