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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
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Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
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Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
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Left Ventricular Diastolic Dysfunction Is Associated with Poor Functional Outcomes after Endovascular Thrombectomy.

Tony Y W Li1, Emma M S Toh2, Ying Ying Koh2

  • 1Department of Cardiology, National University Heart Centre Singapore, 1E Kent Ridge Road, NUHS Tower Block Level 9, Singapore 119228, Singapore.

Journal of Cardiovascular Development and Disease
|March 27, 2024
PubMed
Summary

Left ventricular diastolic dysfunction (LVDD) is linked to worse functional recovery in acute ischemic stroke patients undergoing endovascular thrombectomy (ET). LVDD did not significantly impact in-hospital mortality in this study. Further research is recommended.

Keywords:
atrial fibrillationcerebrovascular diseasediastolic dysfunctionembolismischaemic strokestroke

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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
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Area of Science:

  • Cardiology
  • Neurology
  • Stroke Medicine

Background:

  • Endovascular thrombectomy (ET) has improved outcomes for acute ischemic stroke (AIS) with large vessel occlusion (LVO).
  • Left ventricular diastolic dysfunction (LVDD) is associated with poor prognosis in other cardiovascular conditions.
  • The impact of LVDD on functional recovery after stroke remains unclear.

Purpose of the Study:

  • To investigate the relationship between LVDD and clinical outcomes in patients with LVO AIS who underwent ET.
  • To assess the association of LVDD with short-term mortality and functional recovery.

Main Methods:

  • Retrospective cohort study of 261 LVO AIS patients who underwent ET.
  • Correlation of LVDD with in-hospital mortality and modified Rankin Scale (mRS) score at 3 months (0-2 for good recovery).

Main Results:

  • LVDD was present in 31.4% of patients.
  • LVDD was associated with poorer functional recovery at 3 months (OR 2.18, 95% CI 1.04-4.54, p=0.038).
  • LVDD was not significantly associated with increased in-hospital mortality (OR 2.18, 95% CI 0.60-7.99, p=0.240) after adjustment.

Conclusions:

  • LVDD may indicate poorer outcomes in patients undergoing ET for LVO AIS, beyond traditional echocardiographic measures.
  • Further investigation into the role of LVDD in stroke recovery is warranted.