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Types of RNA01:23

Types of RNA

63.6K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
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RNA Polymerase II Accessory Proteins02:36

RNA Polymerase II Accessory Proteins

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Proteins that regulate transcription can do so either via direct contact with RNA Polymerase or through indirect interactions facilitated by adaptors, mediators, histone-modifying proteins, and nucleosome remodelers. Direct interactions to activate transcription is seen in bacteria as well as in some eukaryotic genes. In these cases, upstream activation sequences are adjacent to the promoters, and the activator proteins interact directly with the transcriptional machinery. For example, in...
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Nucleic acids02:43

Nucleic acids

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Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
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Nucleic Acids02:43

Nucleic Acids

44.1K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
44.1K
Riboswitches01:56

Riboswitches

8.1K
Riboswitches are non-coding mRNA domains that regulate the transcription and translation of downstream genes without the help of proteins. Riboswitches bind directly to a metabolite and can form unique stem-loop or hairpin structures in response to the amount of the metabolite present. They have two distinct regions – a metabolite-binding aptamer and an expression platform.
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...
8.1K
RNA Stability01:53

RNA Stability

33.5K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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Related Experiment Video

Updated: Jun 29, 2025

Capture and Identification of RNA-binding Proteins by Using Click Chemistry-assisted RNA-interactome Capture CARIC Strategy
09:36

Capture and Identification of RNA-binding Proteins by Using Click Chemistry-assisted RNA-interactome Capture CARIC Strategy

Published on: October 19, 2018

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RNA-Binding Proteins in Cardiomyopathies.

De-Li Shi1,2

  • 1Department of Medical Research, Affiliated Hospital of Guangdong Medical University, Zhanjiang 524001, China.

Journal of Cardiovascular Development and Disease
|March 27, 2024
PubMed
Summary

RNA-binding proteins are crucial for heart development and function. Their dysfunction causes cardiomyopathies, but targeting them offers potential therapeutic strategies for heart disease.

Keywords:
IGF2BP2RBFOXRBM20RBM24RBPMSRNA-binding proteinYTHDC1cardiomyopathypost-transcriptional regulation

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Novel RNA-Binding Proteins Isolation by the RaPID Methodology
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Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions
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Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

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Related Experiment Videos

Last Updated: Jun 29, 2025

Capture and Identification of RNA-binding Proteins by Using Click Chemistry-assisted RNA-interactome Capture CARIC Strategy
09:36

Capture and Identification of RNA-binding Proteins by Using Click Chemistry-assisted RNA-interactome Capture CARIC Strategy

Published on: October 19, 2018

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Novel RNA-Binding Proteins Isolation by the RaPID Methodology
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Novel RNA-Binding Proteins Isolation by the RaPID Methodology

Published on: September 30, 2016

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Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions
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Sample Preparation for Mass Spectrometry-based Identification of RNA-binding Regions

Published on: September 28, 2017

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Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Genetics

Background:

  • Post-transcriptional gene regulation is vital for heart development and disease.
  • RNA-binding proteins mediate cardiac-specific alternative splicing, essential for cardiomyocyte function.
  • Dysfunctional RNA-binding proteins lead to cardiomyopathies, affecting heart structure and function.

Purpose of the Study:

  • To review recent advances in understanding RNA-binding proteins in cardiomyopathies.
  • To highlight the role of RNA-binding proteins in cardiac gene programming.
  • To identify research gaps for future investigations into cardiovascular dysfunction.

Main Methods:

  • Review of recent studies on RNA-binding proteins and cardiovascular diseases.
  • Analysis of functional roles of RNA-binding proteins in animal models.
  • Discussion of implications of specific RNA-binding proteins (RBM20, RBFOX2) in cardiomyopathies.

Main Results:

  • Mutations in RBM20 and RBFOX2 are linked to various cardiomyopathies.
  • RNA-binding proteins are involved in cardiac gene programming and homeostasis.
  • Therapeutic potential exists for targeting RNA-binding proteins to rescue cardiomyopathy and promote cardiac regeneration.

Conclusions:

  • RNA-binding proteins are key regulators in heart development and disease.
  • Dysregulation of these proteins contributes to cardiomyopathies.
  • Targeting RNA-binding proteins presents a promising avenue for cardiovascular therapeutics.