Natural Products Derived from Marine Sponges with Antitumor Potential against Lung Cancer: A Systematic Review
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Alba Ortigosa-Palomo1,2,3, Francisco Quiñonero1,2, Raul Ortiz1,2,3
1Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center (CIBM), 18100 Granada, Spain.
Abstract:
Non-small-cell lung cancer (NSCLC), the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide, has been extensively investigated in the last decade in terms of developing new therapeutic options that increase patient survival. In this context, marine animals are a source of new, interesting bioactive molecules that have been applied to the treatment of different types of cancer. Many efforts have been made to search for new therapeutic strategies to improve the prognosis of lung cancer patients, including new bioactive compounds and cytotoxic drugs from marine sponges. Their antitumoral effect can be explained by several cellular and molecular mechanisms, such as modulation of the cell cycle or induction of apoptosis. Thus, this systematic review aims to summarize the bioactive compounds derived from marine sponges and the mechanisms by which they show antitumor effects against lung cancer, exploring their limitations and the challenges associated with their discovery. The search process was performed in three databases (PubMed, SCOPUS, and Web of Science), yielding a total of 105 articles identified in the last 10 years, and after a screening process, 33 articles were included in this systematic review. The results showed that these natural sponge-derived compounds are a valuable source of inspiration for the development of new drugs. However, more research in this field is needed for the translation of these novel compounds to the clinic.
Insights
Marine sponges offer promising compounds for non-small-cell lung cancer (NSCLC) therapy. Further research is crucial to translate these natural products into clinical treatments for lung cancer patients.
Area of Science:
- Marine Biology
- Oncology
- Pharmacology
Background:
- Non-small-cell lung cancer (NSCLC) is a leading cause of cancer death globally.
- Marine sponges are a rich source of novel bioactive molecules with potential anticancer properties.
- Developing new therapeutic strategies for lung cancer remains a critical unmet need.
Approach:
- Systematic review of scientific literature from PubMed, SCOPUS, and Web of Science.
- Analysis of 105 articles published in the last decade, with 33 included in the review.
- Focus on bioactive compounds from marine sponges and their antitumor mechanisms against lung cancer.
Key Points:
- Marine sponge-derived compounds exhibit antitumor effects through mechanisms like cell cycle modulation and apoptosis induction.
- These natural products serve as valuable leads for novel drug development in oncology.
- Identified limitations and challenges in the discovery and clinical translation of these compounds.
Conclusions:
- Marine sponges represent a significant resource for discovering new lung cancer therapeutics.
- Translating these promising natural compounds into clinical applications requires further dedicated research and development.
- The potential of marine-derived pharmaceuticals in cancer treatment warrants continued investigation.
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