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Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies
Doralyn S Dalisay1,2,3, Chuckcris P Tenebro1, Edna M Sabido1
1Center for Chemical Biology and Biotechnology (C2B2), University of San Agustin, Iloilo City 5000, Philippines.
Marine natural products show promise as apoptosis inducers for cancer therapy. This review covers 21 compounds from diverse marine organisms, detailing their mechanisms, preclinical, and clinical trial data for anticancer applications.
Area of Science:
- Marine natural products
- Biotechnology
- Pharmacology
Background:
- Marine organisms are a rich source of novel bioactive compounds.
- Apoptosis induction is a key strategy in cancer therapy.
- Several marine-derived compounds are in clinical trials for cancer treatment.
Purpose of the Study:
- To review marine-derived compounds as inducers of apoptosis for cancer therapy.
- To examine the properties, mechanisms, and trial data of these compounds.
- To discuss the future prospects of marine-derived anticancer therapies.
Main Methods:
- Literature review of marine-derived compounds.
- Analysis of preclinical and clinical trial data.
- Examination of molecular mechanisms of apoptosis induction.
Main Results:
- 21 marine-derived compounds and their synthetic derivatives were reviewed.
- These compounds target extrinsic and intrinsic apoptotic pathways.
- Data from preclinical and clinical trials support their anticancer potential.
Conclusions:
- Marine-derived compounds offer a promising avenue for novel cancer therapies.
- Further research and clinical development are warranted.
- These compounds have diverse mechanisms of action against various cancers.
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