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  3. A Multiomics Assessment Of Preoperative Exercise In Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series.
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  3. A Multiomics Assessment Of Preoperative Exercise In Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case Series.

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A Multiomics Assessment of Preoperative Exercise in Pancreatic Cancer Survivors Receiving Neoadjuvant Therapy: A Case

Travis Nemkov1, Francesca Cendali1, Monika Dzieciatkowska1

  • 1Department of Biochemistry and Molecular Genetics, Anschutz Medical Campus, University of Colorado, Aurora, CO 80045, USA.

Pathophysiology : the Official Journal of the International Society for Pathophysiology
|March 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Personalized exercise programs can improve physical function and lean mass in pancreatic cancer patients undergoing neoadjuvant treatment (NAT). Molecular analysis reveals exercise modulates inflammation and mitochondrial function, enhancing patient quality of life.

Keywords:
biomarkersexercise oncologylipidomicsmetabolomicspancreatic adenocarcinomapancreatic cancerproteomics

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Area of Science:

  • Oncology
  • Exercise Physiology
  • Molecular Biology

Background:

  • Pancreatic ductal adenocarcinoma (PDAC) patients often experience physical decline during neoadjuvant treatment (NAT).
  • Exercise interventions are being explored to mitigate treatment-induced side effects and improve patient outcomes.

Purpose of the Study:

  • To molecularly characterize the effects of a personalized exercise intervention on physical decline in PDAC patients undergoing NAT.
  • To assess the correlation between molecular changes and improvements in physical function and body composition.

Main Methods:

  • A multi-omics approach was used to analyze plasma samples from PDAC patients before and after a personalized aerobic and resistance exercise program.
  • Physical function was assessed using the 400-meter walk test (MWT) and sit-to-stand test.
  • Body composition was evaluated by measuring lean mass and appendicular skeletal muscle index (ASMI).

    • Main Results:

    • The personalized exercise intervention led to significant molecular alterations in plasma samples.
    • These molecular changes correlated with improvements in lean mass, ASMI, and performance in the MWT and sit-to-stand tests.
    • Observed alterations indicated exercise-induced modulation of inflammation and mitochondrial function markers.

    Conclusions:

    • Personalized exercise is a feasible and beneficial intervention for PDAC patients undergoing NAT, potentially enhancing treatment response and quality of life.
    • Multi-omics assessments can provide valuable insights into the molecular mechanisms underlying exercise benefits in cancer patients.
    • This study supports the integration of multi-omics guided exercise programs into cancer treatment protocols.