Related Experiment Video

Updated: Jul 22, 2026

Methyl-binding DNA capture Sequencing for Patient Tissues
08:40

Methyl-binding DNA capture Sequencing for Patient Tissues

Published on: October 31, 2016

8.6K

Effects of quercetin on the DNA methylation pattern in tumor therapy: an updated review

Qin Wang1,2, Chen Ma1, Nan Wang1

  • 1School of Pharmacy, Southwest Minzu University, Chengdu, Sichuan 610225, China. jiajiawangqin@163.com.

Food & Function
|March 27, 2024
PubMed

Insights

Quercetin shows anti-tumor potential by affecting DNA methylation. Nanoscale delivery may overcome its limitations for effective cancer treatment.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Quercetin is a bioactive flavonoid with antioxidant and anti-tumor properties.
  • It regulates key tumor processes including proliferation, apoptosis, invasion, and spread.
  • Emerging research suggests quercetin influences DNA methylation, a critical factor in tumorigenesis.

Purpose of the Study:

  • To review the structure and properties of quercetin.
  • To explore quercetin's role in modifying DNA methylation in tumors.
  • To discuss the potential of nanoscale delivery systems for quercetin in cancer therapy.

Main Methods:

  • Literature review of quercetin's biochemical properties.
  • Analysis of studies on quercetin's interaction with DNA methylation pathways.
  • Evaluation of nanotechnology-based delivery strategies for quercetin.

Main Results:

  • Quercetin exhibits significant antioxidant and anti-tumor activities.
  • Evidence indicates quercetin can modulate DNA methylation patterns relevant to cancer.
  • Current limitations include poor solubility, short half-life, and inadequate tumor targeting.

Conclusions:

  • Quercetin holds promise as an anti-cancer agent due to its effects on DNA methylation.
  • Nanoscale delivery systems offer a viable approach to enhance quercetin's therapeutic efficacy.
  • Further research into optimized delivery is crucial for clinical translation.

More Related Videos

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer07:50

Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer

Published on: September 18, 2020

5.5K
Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors06:07

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors

Published on: August 5, 2022

2.6K

Related Concept Videos

Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...