Triglyceride-glucose index predicts major adverse cardiovascular events in patients with chronic kidney disease
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View abstract on PubMed
Summary
This summary is machine-generated.The triglyceride-glucose (TyG) index is a significant predictor of major adverse cardiovascular events (MACE) in individuals with chronic kidney disease (CKD). Higher TyG index levels correlate with an increased risk of MACE, highlighting its prognostic value.
Area Of Science
- Cardiology
- Nephrology
- Metabolic Syndrome
Background
- Insulin resistance is a key factor in cardiovascular disease development.
- The triglyceride-glucose (TyG) index is a validated marker for insulin resistance.
- Chronic kidney disease (CKD) patients face a high risk of cardiovascular events.
Purpose Of The Study
- To investigate the association between the TyG index and major adverse cardiovascular events (MACE).
- To evaluate the TyG index as a predictor of cardiovascular outcomes in CKD patients.
Main Methods
- A cohort of 13,517 CKD patients from the Kailuan study was analyzed.
- Patients were stratified into quartiles based on their TyG index.
- Cox regression models were employed to assess the relationship between TyG index and MACE risk over a 13.87-year follow-up period.
Main Results
- A total of 1356 MACEs (including acute myocardial infarction and ischemic stroke) were recorded.
- Higher quartiles of the TyG index were significantly associated with an increased risk of MACE.
- Multivariable analyses confirmed the independent predictive value of the TyG index.
Conclusions
- The TyG index demonstrates a significant association with MACE in patients with CKD.
- The TyG index serves as a novel and valuable predictor for cardiovascular events in the CKD population.
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