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Preliminary Long-Term Biocompatibility Assessment of Penn State University Child Pump.

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Development of the PSU Child Pump.

Christopher Scheib1, Raymond Newswanger1, Joshua Cysyk1

  • 1From the Division of Applied Biomedical Engineering, Department of Surgery, College of Medicine, Penn State University, Hershey, Pennsylvania.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|March 27, 2024
PubMed
Summary
This summary is machine-generated.

The PSU Child Pump, a new pediatric continuous-flow ventricular assist device (cf-VAD), shows promise for treating children with heart failure. Its design minimizes blood trauma, offering a safer option while awaiting heart transplantation.

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Area of Science:

  • Biomedical Engineering
  • Cardiovascular Research
  • Pediatric Cardiology

Background:

  • Pediatric heart failure necessitates advanced mechanical circulatory support.
  • Current ventricular assist devices (VADs) may not be optimally sized or safe for pediatric patients.
  • The Pennsylvania State University (PSU) Child Pump is a novel centrifugal continuous-flow ventricular assist device (cf-VAD) designed for pediatric use.

Purpose of the Study:

  • To evaluate the in-vitro hydraulic and hemodynamic performance of the PSU Child Pump.
  • To assess the blood-contacting surfaces for potential hemolysis.
  • To compare the physical size of the PSU Child Pump with existing VADs in a pediatric mock-up.

Main Methods:

  • In-vitro testing on a mock circulatory loop using ovine blood to assess hydraulic and hemodynamic performance.
  • Evaluation of Normalized Index of Hemolysis (NIH) under four different operating conditions.
  • A mock fit study using a 3D-printed model of a pediatric thoracic cavity to compare device size.

Main Results:

  • The PSU Child Pump demonstrated acceptable hydraulic and hemodynamic performance across tested conditions.
  • Normalized Index of Hemolysis (NIH) values were generally low, indicating minimal blood trauma (ranging from 0.015 ± 0.006 to 0.027 ± 0.013 mg/dl).
  • Mock fit study suggested the PSU Child Pump is appropriately sized for the target pediatric population compared to adult devices.

Conclusions:

  • The PSU Child Pump is a potentially safer and appropriately sized cf-VAD for pediatric heart failure patients.
  • The device shows promise in providing adequate support while minimizing risks of blood trauma.
  • Further development and clinical evaluation are warranted to confirm its efficacy as a bridge to transplant for children.