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Exploring the oncogenic and tumor-suppressive roles of Circ-ADAM9 in cancer
Md Sadique Hussain1, Ehssan Moglad2, Pooja Bansal3
1School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, Rajasthan 302017, India.
Abstract:
Circular RNAs (circRNAs) constitute a recently identified category of closed continuous loop RNA transcripts, serving as a subset of competing endogenous RNAs (ceRNAs) with the capacity to modulate genes by acting as microRNA sponges. In the context of cancer growth, numerous investigations have explored the potential functions of circRNAs, revealing their diverse functions either as oncogenes, promoting cancer progression, or as tumor suppressors, mitigating disease development. Among these, circRNA ADAM9 (Circ-ADAM9) is now recognized as an important player in a variety of mechanisms, both physiological and pathological, especially in cancer. The aberrant expression of Circ-ADAM9 has been observed across multiple human malignancies, implying a significant involvement in tumorigenesis. This comprehensive review aims to synthesize recent findings elucidating the function of Circ-ADAM9 in many malignancies. Additionally, the review explores the possibility of Circ-ADAM9 as a valuable biomarker, offering insights into its prognostic, diagnostic, and therapeutic implications. By summarizing the latest discoveries in this field, the review contributes to our understanding of the multifaceted contribution of Circ-ADAM9 in tumor biology and its potential applications in clinical settings.
Insights
Circular RNAs (circRNAs) are key regulators in cancer. This review focuses on circRNA ADAM9 (Circ-ADAM9), exploring its roles in tumorigenesis and potential as a cancer biomarker.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- Circular RNAs (circRNAs) are non-coding RNAs forming closed loops.
- They function as competing endogenous RNAs (ceRNAs), modulating gene expression via microRNA sponging.
- Aberrant circRNA expression is implicated in various cancers.
Purpose of the Study:
- To review the multifaceted roles of circRNA ADAM9 (Circ-ADAM9) in diverse malignancies.
- To explore the potential of Circ-ADAM9 as a biomarker for cancer diagnosis, prognosis, and therapy.
Main Methods:
- Comprehensive literature review of recent studies on Circ-ADAM9 in cancer.
- Synthesis of findings on Circ-ADAM9's involvement in physiological and pathological mechanisms.
- Analysis of Circ-ADAM9's potential clinical applications.
Main Results:
- Circ-ADAM9 exhibits aberrant expression in multiple human cancers.
- It plays significant roles in tumorigenesis, acting as either an oncogene or tumor suppressor.
- Emerging evidence highlights Circ-ADAM9's potential as a diagnostic and prognostic biomarker.
Conclusions:
- Circ-ADAM9 is a crucial factor in tumor biology across various malignancies.
- Circ-ADAM9 holds promise as a versatile biomarker for cancer management.
- Further research into Circ-ADAM9 could lead to novel therapeutic strategies.
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