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Anlotinib Inhibits Ovarian Cancer and Enhances Cisplatinum Sensitivity via Suppressing NOTCH2 Expression and Stemness

Xiaosheng Xu1, Qun Wang1, Lifei Shen1

  • 1Department of Obstetrics and Gynecology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, P.R. China.

Anticancer Research
|March 27, 2024
PubMed
Abstract

Insights

Anlotinib effectively inhibits ovarian cancer (OC) cell proliferation and migration. This multi-targeted tyrosine kinase inhibitor also enhances chemotherapy sensitivity, showing promise for OC treatment.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Ovarian cancer (OC) poses a poor prognosis, particularly with chemotherapy resistance.
  • Anlotinib, a multi-targeted tyrosine kinase inhibitor, demonstrates efficacy across various cancers.

Purpose of the Study:

  • To investigate the inhibitory effects of anlotinib on ovarian cancer cell proliferation.
  • To determine anlotinib's mechanism in modulating ovarian cancer cell chemosensitivity.

Main Methods:

  • In vitro assays (CCK-8, colony-formation, flow-cytometry, transwell-migration, sphere-formation) were used on OC cell lines.
  • In vivo xenograft mouse models and molecular analyses (RT-qPCR, western blotting) were employed.

Main Results:

  • Anlotinib significantly inhibited proliferation and migration of ovarian cancer cells in vitro.
  • The drug enhanced ovarian cancer cell sensitivity to cisplatin both in vitro and in vivo.
  • Anlotinib suppressed sphere formation and stemness by inhibiting NOTCH2 expression.

Conclusions:

  • Anlotinib demonstrates inhibitory effects on ovarian cancer.
  • The drug enhances cisplatin sensitivity in ovarian cancer, indicating potential clinical utility.
Keywords:
AnlotinibNOTCH2cancer cell stemnesschemosensitivitycisplatinum ovarian cancer

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